| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:200-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | LEFTY1 |
| Gene ID: | 10637 |
| Uniprot ID: | LFTY1_HUMAN |
| Immunogen Region: | 77-366 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 77-366 of human LEFTY1 (NP_066277.1). |
| Immunogen Sequence: | RFSQSFREVAGRFLALEAST HLLVFGMEQRLPPNSELVQA VLRLFQEPVPKAALHRHGRL SPRSARARVTVEWLRVRDDG SNRTSLIDSRLVSVHESGWK AFDVTEAVNFWQQLSRPRQP LLLQVSVQREHLGPLASGAH KLVRFASQGAPAGLGEPQLE LHTLDLGDYGAQGDCDPEAP MTEGTRCCRQEMYIDLQGMK WAENWVLEPPGFLAYECVGT CRQPPEALAFKWPFLGPRQ |
| Post Translational Modifications | The processing of the protein may also occur at the second R-X-X-R site located at AA 132-135. Processing appears to be regulated in a cell-type specific manner. |
| Function | Required for left-right axis determination as a regulator of LEFTY2 and NODAL. |
| Protein Name | Left-Right Determination Factor 1 Left-Right Determination Factor B Protein Lefty-1 Protein Lefty-B |
| Database Links | Reactome: R-HSA-1181150 Reactome: R-HSA-1433617 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Left-Right Determination Factor 1 antibody Anti-Left-Right Determination Factor B antibody Anti-Protein Lefty-1 antibody Anti-Protein Lefty-B antibody Anti-LEFTY1 antibody Anti-LEFTB antibody Anti-LEFTYB antibody Anti-UNQ278 antibody Anti-PRO317 antibody |
Information sourced from Uniprot.org