![Anti-Lck-interacting molecule [LIME] antibody (STJ16101298)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/150013/346910/STJ16101298_1__38807.1681999130.jpg?c=1 "Anti-Lck-interacting molecule [LIME] antibody (STJ16101298)")
![Anti-Lck-interacting molecule [LIME] antibody (STJ16101298)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/150013/346910/STJ16101298_1__38807.1681999130.jpg?c=1 "Anti-Lck-interacting molecule [LIME] antibody (STJ16101298)")
Anti-Lck-interacting molecule [LIME] antibody (STJ16101298)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
ImmunogenBacterially expressed intracellular fragment corresponding to aa 141-295 of human LIME.
General Information
| Short Description | Rabbit polyclonal anti-Lck-interacting molecule [LIME] for use in WB and IHC-P in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | Affinity purified |
| Formulation | Phosphate buffered saline (PBS) solution with 15 mM sodium azide |
| Storage Instruction | Store at 2-8°C for up to 1-year, upon receipt. |
Target Information
| Immunogen | Bacterially expressed intracellular fragment corresponding to aa 141-295 of human LIME. |
Additional Info
| Background | LIME (Lck-interacting molecule) is a 30 kDa double-palmitoylated protein with unusually basic cytoplasmic domain, expressed by T cells. After ligation of CD4 or CD8 T cell coreceptors, LIME is phosphorylated by Src-family kinases and associates with Lck and Fyn kinases and with their negative regulator Csk. Interestingly, Csk-mediated phosphorylation of C-terminal negative-regulatory tyrosine of LIME-associated Lck can result in increase of enzymatic activity compared with the total pool of Lck, thus, LIME serves as a positive regulator of TCR-dependent T cell signaling. However, under some circumstances, LIME may mediate inhibitory signals. |
Information sourced from Uniprot.org