| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | LARS1 |
| Gene ID: | 51520 |
| Uniprot ID: | SYLC_HUMAN |
| Immunogen Region: | 1-270 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human LARS (NP_064502.9). |
| Immunogen Sequence: | MAERKGTAKVDFLKKIEKEI QQKWDTERVFEVNASNLEKQ TSKGKYFVTFPYPYMNGRLH LGHTFSLSKCEFAVGYQRLK GKCCLFPFGLHCTGMPIKAC ADKLKREIELYGCPPDFPDE EEEEEETSVKTEDIIIKDKA KGKKSKAAAKAGSSKYQWGI MKSLGLSDEEIVKFSEAEHW LDYFPPLAIQDLKRMGLKVD WRRSFITTDVNPYYDSFVRW QFLTLRERNKIKFGKRYTI |
| Function | Aminoacyl-tRNA synthetase that catalyzes the specific attachment of leucine to its cognate tRNA (tRNA(Leu)). It performs tRNA aminoacylation in a two-step reaction: Leu is initially activated by ATP to form a leucyl-adenylate (Leu-AMP) intermediate.then the leucyl moiety is transferred to the acceptor 3' end of the tRNA to yield leucyl-tRNA. To improve the fidelity of catalytic reactions, it is also able to hydrolyze misactivated aminoacyl-adenylate intermediates (pre-transfer editing) and mischarged aminoacyl-tRNAs (post-transfer editing). |
| Protein Name | Leucine--Trna Ligase - CytoplasmicLeucyl-Trna SynthetaseLeursClrs |
| Database Links | Reactome: R-HSA-2408522Reactome: R-HSA-379716Reactome: R-HSA-9856649 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Leucine--Trna Ligase - Cytoplasmic antibodyAnti-Leucyl-Trna Synthetase antibodyAnti-Leurs antibodyAnti-Clrs antibodyAnti-LARS1 antibodyAnti-KIAA1352 antibodyAnti-LARS antibody |
Information sourced from Uniprot.org