| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:1000-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | L3MBTL2 |
| Gene ID: | 83746 |
| Uniprot ID: | LMBL2_HUMAN |
| Immunogen Region: | 486-705 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 486-705 of human L3MBTL2 (NP_113676.2). |
| Immunogen Sequence: | PATFCQKNDIELTPPKGYEA QTFNWENYLEKTKSKAAPSR LFNMDCPNHGFKVGMKLEAV DLMEPRLICVATVKRVVHRL LSIHFDGWDSEYDQWVDCES PDIYPVGWCELTGYQLQPPV AAEPATPLKAKEATKKKKKQ FGKKRKRIPPTKTRPLRQGS KKPLLEDDPQGARKISSEPV PGEIIAVRVKEEHLDVASPD KASSPELPVSVENIKQETDD |
| Function | Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Its association with a chromatin-remodeling complex suggests that it may contribute to prevent expression of genes that trigger the cell into mitosis. Binds to monomethylated and dimethylated 'Lys-20' on histone H4. Binds histone H3 peptides that are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. |
| Protein Name | Lethal(3malignant Brain Tumor-Like Protein 2H-L(3mbt-Like Protein 2L(3mbt-Like Protein 2 |
| Database Links | Reactome: R-HSA-4551638Reactome: R-HSA-8953750 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Lethal(3malignant Brain Tumor-Like Protein 2 antibodyAnti-H-L(3mbt-Like Protein 2 antibodyAnti-L(3mbt-Like Protein 2 antibodyAnti-L3MBTL2 antibody |
Information sourced from Uniprot.org