| Function | Neural cell adhesion molecule involved in the dynamics of cell adhesion and in the generation of transmembrane signals at tyrosine kinase receptors. During brain development, critical in multiple processes, including neuronal migration, axonal growth and fasciculation, and synaptogenesis. In the mature brain, plays a role in the dynamics of neuronal structure and function, including synaptic plasticity. |
| Protein Name | Neural Cell Adhesion Molecule L1N-Cam-L1Ncam-L1Cd Antigen Cd171 |
| Database Links | Reactome: R-HSA-210991Reactome: R-HSA-373760Reactome: R-HSA-437239Reactome: R-HSA-445095Reactome: R-HSA-445144 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinCell ProjectionGrowth ConeAxonDendriteColocalized With Shtn1 In Close Apposition With Actin Filaments In Filopodia And Lamellipodia Of Axonalne Growth Cones Of Hippocampal NeuronsIn NeuronsDetected Predominantly In Axons And Cell BodyWeak Localization To Dendrites |
| Alternative Antibody Names | Anti-Neural Cell Adhesion Molecule L1 antibodyAnti-N-Cam-L1 antibodyAnti-Ncam-L1 antibodyAnti-Cd Antigen Cd171 antibodyAnti-L1CAM antibodyAnti-CAML1 antibodyAnti-MIC5 antibody |
Information sourced from Uniprot.org
![Immunofluorescence analysis of HeLa cells using [KO Validated] L1CAM rabbit polyclonal antibody (STJ111291) at dilution of 1:150 (40x lens). Blue: DAPI for nuclear staining.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/91709/371378/STJ111291_3__79394.1713137359.jpg?c=1 "Immunofluorescence analysis of HeLa cells using [KO Validated] L1CAM rabbit polyclonal antibody (STJ111291) at dilution of 1:150 (40x lens). Blue: DAPI for nuclear staining.")
![Immunofluorescence analysis of Neuro-2a cells using [KO Validated] L1CAM rabbit polyclonal antibody (STJ111291) at dilution of 1:150 (40x lens). Blue: DAPI for nuclear staining.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/91709/371380/STJ111291_4__07016.1713137360.jpg?c=1 "Immunofluorescence analysis of Neuro-2a cells using [KO Validated] L1CAM rabbit polyclonal antibody (STJ111291) at dilution of 1:150 (40x lens). Blue: DAPI for nuclear staining.")
![Immunofluorescence analysis of SH-SY5Y cells using [KO Validated] L1CAM rabbit polyclonal antibody (STJ111291) at dilution of 1:150 (40x lens). Blue: DAPI for nuclear staining.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/91709/371382/STJ111291_5__88349.1713137361.jpg?c=1 "Immunofluorescence analysis of SH-SY5Y cells using [KO Validated] L1CAM rabbit polyclonal antibody (STJ111291) at dilution of 1:150 (40x lens). Blue: DAPI for nuclear staining.")
