Host: | Rabbit |
Applications: | WB/IF |
Reactivity: | Human/Mouse/Rat |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | Rabbit polyclonal antibody anti-L1CAM (1143-1257) is suitable for use in Western Blot and Immunofluorescence research applications. |
Clonality: | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
Purification: | Affinity purification |
Dilution Range: | WB 1:500-1:1000 IF/ICC 1:50-1:200 |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: | L1CAM |
Gene ID: | 3897 |
Uniprot ID: | L1CAM_HUMAN |
Immunogen Region: | 1143-1257 |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1143-1257 of human CD171/L1CAM (NP_000416.1). |
Immunogen Sequence: | IKRSKGGKYSVKDKEDTQVD SEARPMKDETFGEYRSLESD NEEKAFGSSQPSLNGDIKPL GSDDSLADYGGSVDVQFNED GSFIGQYSGKKEKEAAGGND SSGATSPINPAVALE |
Function | Neural cell adhesion molecule involved in the dynamics of cell adhesion and in the generation of transmembrane signals at tyrosine kinase receptors. During brain development, critical in multiple processes, including neuronal migration, axonal growth and fasciculation, and synaptogenesis. In the mature brain, plays a role in the dynamics of neuronal structure and function, including synaptic plasticity. |
Protein Name | Neural Cell Adhesion Molecule L1 N-Cam-L1 Ncam-L1 Cd Antigen Cd171 |
Database Links | Reactome: R-HSA-210991 Reactome: R-HSA-373760 Reactome: R-HSA-437239 Reactome: R-HSA-445095 Reactome: R-HSA-445144 |
Cellular Localisation | Cell Membrane Single-Pass Type I Membrane Protein Cell Projection Growth Cone Axon Dendrite Colocalized With Shtn1 In Close Apposition With Actin Filaments In Filopodia And Lamellipodia Of Axonalne Growth Cones Of Hippocampal Neurons In Neurons Detected Predominantly In Axons And Cell Body Weak Localization To Dendrites |
Alternative Antibody Names | Anti-Neural Cell Adhesion Molecule L1 antibody Anti-N-Cam-L1 antibody Anti-Ncam-L1 antibody Anti-Cd Antigen Cd171 antibody Anti-L1CAM antibody Anti-CAML1 antibody Anti-MIC5 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance