| Short Description : | Rabbit polyclonal KREMEN1 (180-380) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | KREMEN1 |
| Gene ID: | 83999 |
| Uniprot ID: | KREM1_HUMAN |
| Immunogen Region: | 180-380 |
| Immunogen Sequence: | YGEAASTECNSVCFGDHTQP CGGDGRIILFDTLVGACGGN YSAMSSVVYSPDFPDTYATG RVCYWTIRVPGASHIHFSFP LFDIRDSADMVELLDGYTHR VLARFHGRSRPPLSFNVSLD FVILYFFSDRINQAQGFAVL YQAVKEELPQERPAVNQTVA EVITEQANLSVSAARSSKVL YVITTSPSHPPQTVPGWTVY G |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 180-380 of human KREMEN1 (NP_001034659.2). |
| Function | Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. In the absence of DKK1, potentiates Wnt-beta-catenin signaling by maintaining LRP5 or LRP6 at the cell membrane. Can trigger apoptosis in a Wnt-independent manner and this apoptotic activity is inhibited upon binding of the ligand DKK1. Plays a role in limb development.attenuates Wnt signaling in the developing limb to allow normal limb patterning and can also negatively regulate bone formation. Modulates cell fate decisions in the developing cochlea with an inhibitory role in hair cell fate specification. |
| Protein Name | Kremen Protein 1Dickkopf ReceptorKringle Domain-Containing Transmembrane Protein 1Kringle-Containing Protein Marking The Eye And The Nose |
| Database Links | Reactome: R-HSA-201681Reactome: R-HSA-3772470Reactome: R-HSA-5339717 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Kremen Protein 1 antibodyAnti-Dickkopf Receptor antibodyAnti-Kringle Domain-Containing Transmembrane Protein 1 antibodyAnti-Kringle-Containing Protein Marking The Eye And The Nose antibodyAnti-KREMEN1 antibodyAnti-KREMEN antibodyAnti-KRM1 antibody |
Information sourced from Uniprot.org
