| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-KMT5C (100-200) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
KMT5C |
| Gene ID: |
84787 |
| Uniprot ID: |
KMT5C_HUMAN |
| Immunogen Region: |
100-200 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 100-200 of human KMT5C (NP_116090.2). |
| Immunogen Sequence: |
FLPESGFTILPCTRYSMETN GAKIVSTRAWKKNEKLELLV GCIAELREADEGLLRAGEND FSIMYSTRKRSAQLWLGPAA FINHDCKPNCKFVPADGNAA C |
| Function | Histone methyltransferase that specifically methylates monomethylated 'Lys-20' (H4K20me1) and dimethylated 'Lys-20' (H4K20me2) of histone H4 to produce respectively dimethylated 'Lys-20' (H4K20me2) and trimethylated 'Lys-20' (H4K20me3) and thus regulates transcription and maintenance of genome integrity. In vitro also methylates unmodified 'Lys-20' (H4K20me0) of histone H4 and nucleosomes. H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. KMT5C is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2). Facilitates TP53BP1 foci formation upon DNA damage and proficient non-homologous end-joining (NHEJ)-directed DNA repair by catalyzing the di- and trimethylation of 'Lys-20' of histone H4. May play a role in class switch reconbination by catalyzing the di- and trimethylation of 'Lys-20' of histone H4. |
| Protein Name | Histone-Lysine N-Methyltransferase Kmt5cLysine N-Methyltransferase 5cLysine-Specific Methyltransferase 5cSuppressor Of Variegation 4-20 Homolog 2Su(Var4-20 Homolog 2Suv4-20h2Histone H4-N-Methyl-L-Lysine20 N-Methyltransferase Kmt5bHistone H4-Lysine20 N-Methyltransferase Kmt5b |
| Database Links | Reactome: R-HSA-3214841 |
| Cellular Localisation | NucleusChromosomeAssociated With Pericentric HeterochromatinCbx1 And Cbx5 Are Required For The Localization To Pericentric Heterochromatin |
| Alternative Antibody Names | Anti-Histone-Lysine N-Methyltransferase Kmt5c antibodyAnti-Lysine N-Methyltransferase 5c antibodyAnti-Lysine-Specific Methyltransferase 5c antibodyAnti-Suppressor Of Variegation 4-20 Homolog 2 antibodyAnti-Su(Var4-20 Homolog 2 antibodyAnti-Suv4-20h2 antibodyAnti-Histone H4-N-Methyl-L-Lysine20 N-Methyltransferase Kmt5b antibodyAnti-Histone H4-Lysine20 N-Methyltransferase Kmt5b antibodyAnti-KMT5C antibodyAnti-SUV420H2 antibodyAnti-PP7130 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
