| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-N-lysine methyltransferase KMT5A (282-332) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:1000-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
KMT5A |
| Gene ID: |
387893 |
| Uniprot ID: |
KMT5A_HUMAN |
| Immunogen Region: |
282-332 |
| Specificity: |
This antibody detects endogenous levels of human SETD8 |
| Immunogen: |
Synthesized peptide derived from human SETD8 AA range: 282-332 |
| Function | Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher-order structure of DNA during mitosis. Involved in chromosome condensation and proper cytokinesis. Nucleosomes are preferred as substrate compared to free histones. Mediates monomethylation of p53/TP53 at 'Lys-382', leading to repress p53/TP53-target genes. Plays a negative role in TGF-beta response regulation and a positive role in cell migration. |
| Protein Name | N-Lysine Methyltransferase Kmt5aH4-K20-Hmtase Kmt5aHistone-Lysine N-Methyltransferase Kmt5aLysine N-Methyltransferase 5aLysine-Specific Methylase 5aPr/Set Domain-Containing Protein 07Pr-Set7Pr/Set07Set Domain-Containing Protein 8 |
| Database Links | Reactome: R-HSA-2299718Reactome: R-HSA-3214841Reactome: R-HSA-6804760 |
| Cellular Localisation | NucleusChromosomeSpecifically Localizes To Mitotic ChromosomesColocalized With Sirt2 At Mitotic FociAssociates With Chromosomes During MitosisAssociation Is Increased In A H(2)O(2)-Induced Oxidative Stress-Dependent MannerAssociates With Silent Chromatin On Euchromatic ArmsNot Associated With Constitutive Heterochromatin |
| Alternative Antibody Names | Anti-N-Lysine Methyltransferase Kmt5a antibodyAnti-H4-K20-Hmtase Kmt5a antibodyAnti-Histone-Lysine N-Methyltransferase Kmt5a antibodyAnti-Lysine N-Methyltransferase 5a antibodyAnti-Lysine-Specific Methylase 5a antibodyAnti-Pr/Set Domain-Containing Protein 07 antibodyAnti-Pr-Set7 antibodyAnti-Pr/Set07 antibodyAnti-Set Domain-Containing Protein 8 antibodyAnti-KMT5A antibodyAnti-PRSET7 antibodyAnti-SET07 antibodyAnti-SET8 antibodyAnti-SETD8 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
