Anti-KLKB1 antibody (20-300) (STJ27271)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal KLKB1 (20-300) antibody for use in WB, IHC-P and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.09% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | KLKB1 |
| Gene ID | 3818 |
| Uniprot ID | KLKB1_HUMAN |
| Immunogen Region | 20-300 |
| Immunogen Sequence | GCLTQLYENAFFRGGDVASM YTPNAQYCQMRCTFHPRCLL FSFLPASSINDMEKRFGCFL KDSVTGTLPKVHRTGAVSGH SLKQCGHQISACHRDIYKGV DMRGVNFNVSKVSSVEECQK RCTSNIRCQFFSYATQTFHK AEYRNNCLLKYSPGGTPTAI KVLSNVESGFSLKPCALSEI GCHMNIFQHLAFSDVDVARV LTPDAFVCRTICTYHPNCLF FTFYTNVWKIESQRNVCLL |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 20-300 of human KLKB1 (NP_000883.2). |
Additional Info
| Tissue Specificity | Found in plasma (at protein level). |
| Function | Participates in the surface-dependent activation of blood coagulation. Activates, in a reciprocal reaction, coagulation factor XII/F12 after binding to negatively charged surfaces. Releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin. |
| Protein Name | Plasma KallikreinFletcher FactorKininogeninPlasma PrekallikreinPkk Cleaved Into - Plasma Kallikrein Heavy Chain - Plasma Kallikrein Light Chain |
| Database Links | Reactome: R-HSA-140837Reactome: R-HSA-1592389Reactome: R-HSA-9657688Reactome: R-HSA-9657689 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Plasma Kallikrein antibodyAnti-Fletcher Factor antibodyAnti-Kininogenin antibodyAnti-Plasma Prekallikrein antibodyAnti-Pkk Cleaved Into - Plasma Kallikrein Heavy Chain - Plasma Kallikrein Light Chain antibodyAnti-KLKB1 antibodyAnti-KLK3 antibody |
Information sourced from Uniprot.org