| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-KLK8 (33-200) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:200-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
KLK8 |
| Gene ID: |
11202 |
| Uniprot ID: |
KLK8_HUMAN |
| Immunogen Region: |
33-200 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 33-200 of human KLK8 (NP_009127.1). |
| Immunogen Sequence: |
VLGGHECQPHSQPWQAALFQ GQQLLCGGVLVGGNWVLTAA HCKKPKYTVRLGDHSLQNKD GPEQEIPVVQSIPHPCYNSS DVEDHNHDLMLLQLRDQASL GSKVKPISLADHCTQPGQKC TVSGWGTVTSPRENFPDTLN CAEVKIFPQKKCEDAYPGQI TDGMVCAG |
| Tissue Specificity | Isoform 1 is predominantly expressed in the pancreas. Isoform 2 is expressed in adult brain and hippocampus. Isoform 1 and isoform 2 are found in fetal brain and placenta. Detected in salivary gland, uterus, thymus, breast, testis and kidney but not in spleen, liver, lung or normal ovarian tissue. Displays an 11.5-fold increase in Alzheimer disease hippocampus compared to controls and is overexpressed in some ovarian carcinomas. Expressed at low levels in normal skin while high levels are found in psoriasis vulgaris, seborrheic keratosis, lichen planus and squamous cell carcinoma skin samples. Expressed in the keratinocytes. |
| Function | Serine protease which is capable of degrading a number of proteins such as casein, fibrinogen, kininogen, fibronectin and collagen type IV. Also cleaves L1CAM in response to increased neural activity. Induces neurite outgrowth and fasciculation of cultured hippocampal neurons. Plays a role in the formation and maturation of orphan and small synaptic boutons in the Schaffer-collateral pathway, regulates Schaffer-collateral long-term potentiation in the hippocampus and is required for memory acquisition and synaptic plasticity. Involved in skin desquamation and keratinocyte proliferation. Plays a role in the secondary phase of pathogenesis following spinal cord injury. |
| Protein Name | Kallikrein-8Hk8NeuropsinNpOvasinSerine Protease 19Serine Protease Tadg-14Tumor-Associated Differentially Expressed Gene 14 Protein |
| Database Links | Reactome: R-HSA-6809371 |
| Cellular Localisation | SecretedCytoplasmShows A Cytoplasmic Distribution In The Keratinocytes |
| Alternative Antibody Names | Anti-Kallikrein-8 antibodyAnti-Hk8 antibodyAnti-Neuropsin antibodyAnti-Np antibodyAnti-Ovasin antibodyAnti-Serine Protease 19 antibodyAnti-Serine Protease Tadg-14 antibodyAnti-Tumor-Associated Differentially Expressed Gene 14 Protein antibodyAnti-KLK8 antibodyAnti-NRPN antibodyAnti-PRSS19 antibodyAnti-TADG14 antibodyAnti-UNQ283 antibodyAnti-PRO322 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
