| Short Description : | Rabbit polyclonal KLK11 (1-250) antibody for use in WB, IHC-P and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/IHC-P/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000IHC-P:1:100-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | KLK11 |
| Gene ID: | 11012 |
| Uniprot ID: | KLK11_HUMAN |
| Immunogen Region: | 1-250 |
| Immunogen Sequence: | MRILQLILLALATGLVGGET RIIKGFECKPHSQPWQAALF EKTRLLCGATLIAPRWLLTA AHCLKPRYIVHLGQHNLQKE EGCEQTRTATESFPHPGFNN SLPNKDHRNDIMLVKMASPV SITWAVRPLTLSSRCVTAGT SCLISGWGSTSSPQLRLPHT LRCANITIIEHQKCENAYPG NITDTMVCASVQEGGKDSCQ GDSGGPLVCNQSLQGIISWG QDPCAITRKPGVYTKVCKY |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human KLK11 (NP_001129504.1). |
| Tissue Specificity | Expressed in brain, skin and prostate. Isoform 1 is expressed preferentially in brain. Isoform 2 is expressed in prostate. Present in seminal plasma at concentrations ranging from 2 to 37 microg/mL (at protein level). |
| Post Translational Modifications | About 40% of KLK11 is inactivated by internal cleavage after Arg-188. This proteolytic inactivation may be effected by plasminogen. |
| Function | Possible multifunctional protease. Efficiently cleaves 'bz-Phe-Arg-4-methylcoumaryl-7-amide', a kallikrein substrate, and weakly cleaves other substrates for kallikrein and trypsin. Cleaves synthetic peptides after arginine but not lysine residues. |
| Protein Name | Kallikrein-11Hk11HippostasinSerine Protease 20Trypsin-Like Protease Cleaved Into - Kallikrein-11 Inactive Chain 1 - Kallikrein-11 Inactive Chain 2 |
| Database Links | |
| Cellular Localisation | Isoform 1: SecretedIsoform 2: Golgi ApparatusSecreted |
| Alternative Antibody Names | Anti-Kallikrein-11 antibodyAnti-Hk11 antibodyAnti-Hippostasin antibodyAnti-Serine Protease 20 antibodyAnti-Trypsin-Like Protease Cleaved Into - Kallikrein-11 Inactive Chain 1 - Kallikrein-11 Inactive Chain 2 antibodyAnti-KLK11 antibodyAnti-PRSS20 antibodyAnti-TLSP antibodyAnti-UNQ649 antibodyAnti-PRO1279 antibody |
Information sourced from Uniprot.org
![Immunofluorescence analysis of U-2 OS cells using [KO Validated] Galectin 3/LGALS3 Rabbit polyclonal antibody (STJ115467) at dilution of 1:100. Secondary antibody: Cy3 Goat Anti-Rabbit IgG (H+L) at 1:500 dilution. Blue: DAPI for nuclear staining.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/600x533/products/94495/376135/STJ115467_1__98008.1713143107.jpg?c=1 "Immunofluorescence analysis of U-2 OS cells using [KO Validated] Galectin 3/LGALS3 Rabbit polyclonal antibody (STJ115467) at dilution of 1:100. Secondary antibody: Cy3 Goat Anti-Rabbit IgG (H+L) at 1:500 dilution. Blue: DAPI for nuclear staining.")
