| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IHC-P:1:100-1:500ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | KLK1 |
| Gene ID: | 3816 |
| Uniprot ID: | KLK1_HUMAN |
| Immunogen Region: | 25-262 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 25-262 of human KLK1 (NP_002248.1). |
| Immunogen Sequence: | IVGGWECEQHSQPWQAALYH FSTFQCGGILVHRQWVLTAA HCISDNYQLWLGRHNLFDDE NTAQFVHVSESFPHPGFNMS LLENHTRQADEDYSHDLMLL RLTEPADTITDAVKVVELPT EEPEVGSTCLASGWGSIEPE NFSFPDDLQCVDLKILPNDE CKKAHVQKVTDFMLCVGHLE GGKDTCVGDSGGPLMCDGVL QGVTSWGYVPCGTPNKPSVA VRVLSYVKWIEDTIAENS |
| Tissue Specificity | Isoform 2 is expressed in pancreas, salivary glands, kidney, colon, prostate gland, testis, spleen and the colon adenocarcinoma cell line T84. |
| Post Translational Modifications | The O-linked polysaccharides on Ser-93, Ser-104 and Ser-167 are probably the mucin type linked to GalNAc. In PubMed:3163150, GalNAc was detected with the corresponding peptides but not located. |
| Function | Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin. (Microbial infection) Cleaves Neisseria meningitidis NHBA in saliva.Neisseria is an obligate commensal of the nasopharyngeal mucosa. |
| Protein Name | Kallikrein-1Kidney/Pancreas/Salivary Gland KallikreinTissue Kallikrein |
| Database Links | Reactome: R-HSA-381426 |
| Alternative Antibody Names | Anti-Kallikrein-1 antibodyAnti-Kidney/Pancreas/Salivary Gland Kallikrein antibodyAnti-Tissue Kallikrein antibodyAnti-KLK1 antibody |
Information sourced from Uniprot.org