Western blot analysis of lysates from wild type (WT) and 293T cells transfected with KLF15 using KLF15 Rabbit polyclonal antibody (STJ29274) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 30s.

Anti-KLF15 antibody (1-260) (STJ29274)

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STJ29274
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Host: Rabbit
Applications: WB/ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: WB:1:500-1:2000
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: KLF15
Gene ID: 28999
Uniprot ID: KLF15_HUMAN
Immunogen Region: 1-260
Specificity: Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human KLF15 (NP_054798.1).
Immunogen Sequence: MVDHLLPVDENFSSPKCPVG YLGDRLVGRRAYHMLPSPVS EDDSDASSPCSCSSPDSQAL CSCYGGGLGTESQDSILDFL LSQATLGSGGGSGSSIGASS GPVAWGPWRRAAAPVKGEHF CLPEFPLGDPDDVPRPFQPT LEEIEEFLEENMEPGVKEVP EGNSKDLDACSQLSAGPHKS HLHPGSSGRERCSPPPGGAS AGGAQGPGGGPTPDGPIPVL LQIQPVPVKQESGTGPASP
Tissue Specificity Highly expressed in liver, skeletal muscle, and kidney. Expressed in cardiomyocytes. Expression is highly reduced in cardiac tissue of patients with non-ischemic cardiomyopathy and aortic aneurysm, and in glomerular disease. Not expressed in bone marrow or lymphoid tissues.
Function Transcriptional regulator that binds to the GA element of the CLCNKA promoter. Binds to the KCNIP2 promoter and regulates KCNIP2 circadian expression in the heart. Is a repressor of CCN2 expression, involved in the control of cardiac fibrosis. It is also involved in the control of cardiac hypertrophy acting through the inhibition of MEF2A and GATA4. Involved in podocyte differentiation. Inhibits MYOCD activity. Is a negative regulator of TP53 acetylation. Inhibits NF-kappa-B activation through repression of EP300-dependent RELA acetylation.
Protein Name Krueppel-Like Factor 15
Kidney-Enriched Krueppel-Like Factor
Database Links Reactome: R-HSA-1368108
Cellular Localisation Nucleus
Alternative Antibody Names Anti-Krueppel-Like Factor 15 antibody
Anti-Kidney-Enriched Krueppel-Like Factor antibody
Anti-KLF15 antibody
Anti-KKLF antibody

Information sourced from Uniprot.org

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