Anti-KLB antibody (720-990) (STJ118077)

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STJ118077
€140.63 - €655.63
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Host: Rabbit
Applications: WB/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: WB:1:500-1:2000
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: KLB
Gene ID: 152831
Uniprot ID: KLOTB_HUMAN
Immunogen Region: 720-990
Specificity: Recombinant fusion protein containing a sequence corresponding to amino acids 720-990 of human KLB (NP_783864.1).
Immunogen Sequence: ALAWRLYDRQFRPSQRGAVS LSLHADWAEPANPYADSHWR AAERFLQFEIAWFAEPLFKT GDYPAAMREYIASKHRRGLS SSALPRLTEAERRLLKGTVD FCALNHFTTRFVMHEQLAGS RYDSDRDIQFLQDITRLSSP TRLAVIPWGVRKLLRWVRRN YGDMDIYITASGIDDQALED DRLRKYYLGKYLQEVLKAYL IDKVRIKGYYAFKLAEEKSK PRFGFFTSDFKAKSSIQFY
Function Contributes to the transcriptional repression of cholesterol 7-alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in bile acid synthesis. Probably inactive as a glycosidase. Increases the ability of FGFR1 and FGFR4 to bind FGF21.
Protein Name Beta-Klotho
Bkl
Betaklotho
Klotho Beta-Like Protein
Database Links Reactome: R-HSA-109704
Reactome: R-HSA-1257604
Reactome: R-HSA-1307965
Reactome: R-HSA-2219530
Reactome: R-HSA-5654228
Reactome: R-HSA-5654712
Reactome: R-HSA-5654719
Reactome: R-HSA-5654720
Reactome: R-HSA-5654733
Reactome: R-HSA-5673001
Reactome: R-HSA-6811558
Cellular Localisation Cell Membrane
Single-Pass Type Iii Membrane Protein
Alternative Antibody Names Anti-Beta-Klotho antibody
Anti-Bkl antibody
Anti-Betaklotho antibody
Anti-Klotho Beta-Like Protein antibody
Anti-KLB antibody

Information sourced from Uniprot.org