| Function | Receptor for metastin (kisspeptin-54 or kp-54), a C-terminally amidated peptide of KiSS1. KiSS1 is a metastasis suppressor protein that suppresses metastases in malignant melanomas and in some breast carcinomas without affecting tumorigenicity. The metastasis suppressor properties may be mediated in part by cell cycle arrest and induction of apoptosis in malignant cells. The receptor is essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/KISS1R system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood. The receptor is also probably involved in the regulation and fine-tuning of trophoblast invasion generated by the trophoblast itself. Analysis of the transduction pathways activated by the receptor identifies coupling to phospholipase C and intracellular calcium release through pertussis toxin-insensitive G(q) proteins. |
| Protein Name | Kiss-1 ReceptorKiss-1rG-Protein Coupled Receptor 54G-Protein Coupled Receptor Ot7t175Hot7t175Hypogonadotropin-1Kisspeptins ReceptorMetastin Receptor |
| Database Links | Reactome: R-HSA-375276Reactome: R-HSA-416476 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Kiss-1 Receptor antibodyAnti-Kiss-1r antibodyAnti-G-Protein Coupled Receptor 54 antibodyAnti-G-Protein Coupled Receptor Ot7t175 antibodyAnti-Hot7t175 antibodyAnti-Hypogonadotropin-1 antibodyAnti-Kisspeptins Receptor antibodyAnti-Metastin Receptor antibodyAnti-KISS1R antibodyAnti-AXOR12 antibodyAnti-GPR54 antibody |
Information sourced from Uniprot.org
