• Immunohistochemistry of mouse kidney with Anti-KIRREL primary antibody (STJ501885) at 1:100 dilution in Buffer. Section was treated with DAB and Haematoxylin stain. Magnification is at 40X.

Anti-KIRREL antibody (200-250) (STJ501885)

SKU:
STJ501885-100

£481.50
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Host: Rabbit
Applications: CM/ELISA/IF/IHC/IP/WB
Reactivity: Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-KIRREL (200-250) is suitable for use in Confocal Microscopy, ELISA, Immunofluorescence, Immunohistochemistry, Immunoprecipitation and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Purification: Affinity Purified
Concentration: 0.45-0.65 µg/µl
Dilution Range: WB: 1:250
DB: 1:10, 000
ELISA: 1:10, 000
IP: 1:250
IHC: 1:250
ICC: 1:250
IF: 1:250
CFM: 1:250
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: Kirrel1
Gene ID: 170643
Uniprot ID: KIRR1_MOUSE
Immunogen Region: 200-250
Specificity: Extracellular domain.
Immunogen: Synthetic peptide taken within amino acid region 200-250 on mouse Neph1 protein.
Tissue Specificity Abundantly expressed in kidney. Specifically expressed in podocytes of kidney glomeruli.
Post Translational Modifications Phosphorylation probably regulates the interaction with NPHS2. Phosphorylated at Tyr-637 and Tyr-638 by FYN, leading to GRB2 binding. N-glycosylated.
Function Required for proper function of the glomerular filtration barrier. It is involved in the maintenance of a stable podocyte architecture with interdigitating foot processes connected by specialized cell-cell junctions, known as the slit diaphragm. Is a signaling protein that needs the presence of TEC kinases to fully trans-activate the transcription factor AP-1.
Protein Name Kin Of Irre-Like Protein 1
Kin Of Irregular Chiasm-Like Protein 1
Nephrin-Like Protein 1
Database Links Reactome: R-MMU-373753
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Predominantly Located At Podocyte Slit Diaphragm
Alternative Antibody Names Anti-Kin Of Irre-Like Protein 1 antibody
Anti-Kin Of Irregular Chiasm-Like Protein 1 antibody
Anti-Nephrin-Like Protein 1 antibody
Anti-Kirrel1 antibody
Anti-Kirrel antibody
Anti-Neph1 antibody

Information sourced from Uniprot.org

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