| Tissue Specificity | Distributed throughout the CNS but is highly enriched in subsets of neurons. |
| Function | Microtubule-dependent motor required for slow axonal transport of neurofilament proteins (NFH, NFM and NFL). Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner. The ZFYVE27-KIF5A complex contributes to the vesicular transport of VAPA, VAPB, SURF4, RAB11A, RAB11B and RTN3 proteins in neurons. Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation. |
| Protein Name | Kinesin Heavy Chain Isoform 5aKinesin Heavy Chain Neuron-Specific 1Neuronal Kinesin Heavy ChainNkhc |
| Database Links | Reactome: R-HSA-2132295Reactome: R-HSA-264876Reactome: R-HSA-5625970Reactome: R-HSA-6811434Reactome: R-HSA-983189 |
| Cellular Localisation | CytoplasmPerinuclear RegionCytoskeletonPerikaryonConcentrated In The Cell Body Of The NeuronsParticularly In The Perinuclear Region |
| Alternative Antibody Names | Anti-Kinesin Heavy Chain Isoform 5a antibodyAnti-Kinesin Heavy Chain Neuron-Specific 1 antibodyAnti-Neuronal Kinesin Heavy Chain antibodyAnti-Nkhc antibodyAnti-KIF5A antibodyAnti-NKHC1 antibody |
Information sourced from Uniprot.org
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