| Applications: | WB/IP/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | S7MR |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:1000IP:0.5 Mu g-4 Mu g antibody for 200 Mu g-400 Mu g extracts of whole cellsELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | KIF23 |
| Gene ID: | 9493 |
| Uniprot ID: | KIF23_HUMAN |
| Immunogen Region: | 801-960 |
| Immunogen Sequence: | NAPPIRLRHRRSRSAGDRWV DHKPASNMQTETVMQPHVPH AITVSVANEKALAKCEKYML THQELASDGEIETKLIKGDI YKTRGGGQSVQFTDIETLKQ ESPNGSRKRRSSTVAPAQPD GAESEWTDVETRCSVAVEMR AGSQLGPGYQHHAQPKRKKP |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 801-960 of human KIF23 (Q02241). |
| Tissue Specificity | Widely expressed. |
| Post Translational Modifications | Ubiquitinated. Deubiquitinated by USP8/UBPY. |
| Function | Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Essential for cytokinesis in Rho-mediated signaling. Required for the localization of ECT2 to the central spindle. Plus-end-directed motor enzyme that moves antiparallel microtubules in vitro. |
| Protein Name | Kinesin-Like Protein Kif23Kinesin-Like Protein 5Mitotic Kinesin-Like Protein 1 |
| Database Links | Reactome: R-HSA-2132295Reactome: R-HSA-6811434Reactome: R-HSA-68884Reactome: R-HSA-983189 |
| Cellular Localisation | NucleusCytoplasmCytoskeletonSpindleMidbodyMidbody RingLocalizes To The Interzone Of Mitotic SpindlesDetected At The Midbody During Later Stages Of Mitotic Cytokinesis |
| Alternative Antibody Names | Anti-Kinesin-Like Protein Kif23 antibodyAnti-Kinesin-Like Protein 5 antibodyAnti-Mitotic Kinesin-Like Protein 1 antibodyAnti-KIF23 antibodyAnti-KNSL5 antibodyAnti-MKLP1 antibody |
Information sourced from Uniprot.org
