| Host: |
Rabbit |
| Applications: |
WB/IHC/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-KIF14 (1399-1648) is suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:1000-1:2000IHC-P 1:50-1:200IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
KIF14 |
| Gene ID: |
9928 |
| Uniprot ID: |
KIF14_HUMAN |
| Immunogen Region: |
1399-1648 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1399-1648 of human KIF14 (NP_055690.1). |
| Immunogen Sequence: |
LENGNNKAASVQEEFMDAVC DGVGLGMKILLDSGLEKAKE LQHELFRQCTKNEVTKEMKT NAMGLIRSLENIFAESKIKS FRRQVQEENFEYQDFKRMVN RAPEFLKLKHCLEKAIEIII SALKGCHSDINLLQTCVESI RNLASDFYSDFSVPSTSVGS YESRVTHIVHQELESLAKSL LFCFESEESPDLLKPWETYN QNTKEEHQQSKSSGIDGSKN KGVPKRVYELHGSSPAVSS |
| Function | Microtubule motor protein that binds to microtubules with high affinity through each tubulin heterodimer and has an ATPase activity. Plays a role in many processes like cell division, cytokinesis and also in cell proliferation and apoptosis. During cytokinesis, targets to central spindle and midbody through its interaction with PRC1 and CIT respectively. Regulates cell growth through regulation of cell cycle progression and cytokinesis. During cell cycle progression acts through SCF-dependent proteasomal ubiquitin-dependent protein catabolic process which controls CDKN1B degradation, resulting in positive regulation of cyclins, including CCNE1, CCND1 and CCNB1. During late neurogenesis, regulates the cerebellar, cerebral cortex and olfactory bulb development through regulation of apoptosis, cell proliferation and cell division. Also is required for chromosome congression and alignment during mitotic cell cycle process. Regulates cell spreading, focal adhesion dynamics, and cell migration through its interaction with RADIL resulting in regulation of RAP1A-mediated inside-out integrin activation by tethering RADIL on microtubules. |
| Protein Name | Kinesin-Like Protein Kif14 |
| Database Links | Reactome: R-HSA-5625900Reactome: R-HSA-9696270Reactome: R-HSA-9696273 |
| Cellular Localisation | NucleusCytoplasmCytoskeletonSpindleMidbodyNuclear Localization Observed During InterphaseNuclear Localization Triggered By Entry Into MitosisCytoplasmic In InterphaseCytoplasmic In Metaphase CellsFrom Prophase To MetaphaseAccumulates At The Developing Spindle Poles And Their Associated MicrotubulesDuring AnaphaseAccumulates At The Spindle MidzoneLocalization To The Central Spindle And Midbody During Anaphase Is Dependent Upon Prc1 And Cit PresenceIn Cells Ready To Undergo AbscissionConcentrates At The Contractile Ring |
| Alternative Antibody Names | Anti-Kinesin-Like Protein Kif14 antibodyAnti-KIF14 antibodyAnti-KIAA0042 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
