Host: |
Rabbit |
Applications: |
WB/IHC/IP |
Reactivity: |
Human/Mouse/Rat |
Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: |
Rabbit monoclonal antibody anti-KHSRP (1-180) is suitable for use in Western Blot, Immunohistochemistry and Immunoprecipitation research applications. |
Clonality: |
Monoclonal |
Clone ID: |
S9MR |
Conjugation: |
Unconjugated |
Isotype: |
IgG |
Formulation: |
PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH7.3. |
Purification: |
Affinity purification |
Dilution Range: |
WB 1:500-1:1000IHC-P 1:50-1:200IP 1:500-1:1000 |
Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: |
KHSRP |
Gene ID: |
8570 |
Uniprot ID: |
FUBP2_HUMAN |
Immunogen Region: |
1-180 |
Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human KHSRP (Q92945). |
Immunogen Sequence: |
MSDYSTGGPPPGPPPPAGGG GGAGGAGGGPPPGPPGAGDR GGGGPGGGGPGGGSAGGPSQ PPGGGGPGIRKDAFADAVQR ARQIAAKIGGDAATTVNNST PDFGFGGQKRQLEDGDQPES KKLASQGDSISSQLGPIHPP PRTSMTEEYRVPDGMVGLII GRGGEQINKIQQDSGCKVQI |
Tissue Specificity | Detected in neural and non-neural cell lines. |
Post Translational Modifications | Phosphorylation at Ser-193 leads to the unfolding of the unstable KH domain 1, creating a site for 14-3-3 YWHAZ binding, which promotes nuclear localization and impairs the RNA degradation function. |
Function | Binds to the dendritic targeting element and may play a role in mRNA trafficking. Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly by recruiting degradation machinery to ARE-containing mRNAs. |
Protein Name | Far Upstream Element-Binding Protein 2Fuse-Binding Protein 2Kh Type-Splicing Regulatory ProteinKsrpP75 |
Database Links | Reactome: R-HSA-380994Reactome: R-HSA-450604 |
Cellular Localisation | NucleusCytoplasmA Small Proportion Is Also Found In The Cytoplasm Of Neuronal Cell Bodies And Dendrites |
Alternative Antibody Names | Anti-Far Upstream Element-Binding Protein 2 antibodyAnti-Fuse-Binding Protein 2 antibodyAnti-Kh Type-Splicing Regulatory Protein antibodyAnti-Ksrp antibodyAnti-P75 antibodyAnti-KHSRP antibodyAnti-FUBP2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance