| Function | Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation. Plays a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression by acting as a link between T-box factors and the SMARCA4-containing SWI/SNF remodeling complex. |
| Protein Name | Lysine-Specific Demethylase 6bJmjc Domain-Containing Protein 3Jumonji Domain-Containing Protein 3Histone H3-Trimethyl-L-Lysine(27 Demethylase 6b |
| Database Links | Reactome: R-MMU-2559580Reactome: -MMU-3214842 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Lysine-Specific Demethylase 6b antibodyAnti-Jmjc Domain-Containing Protein 3 antibodyAnti-Jumonji Domain-Containing Protein 3 antibodyAnti-Histone H3-Trimethyl-L-Lysine(27 Demethylase 6b antibodyAnti-Kdm6b antibodyAnti-Jmjd3 antibodyAnti-Kiaa0346 antibody |
Information sourced from Uniprot.org
