| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 IF/ICC:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | Kdm6b |
| Gene ID: | 216850 |
| Uniprot ID: | KDM6B_MOUSE |
| Immunogen Region: | 90-1641 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 90-190 of mouse Kdm6b (NP_001017426.1). |
| Immunogen Sequence: | LESLHGCVQALLREPAQPGL WEQLGQLYESEHDSEEAVCC YHRALRYGGSFAELGPRIGR LQQAQLWNFHAGSCQHRAKV LPPLEQVWNLLHLEHKRNYG A |
| Function | Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation. Plays a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression by acting as a link between T-box factors and the SMARCA4-containing SWI/SNF remodeling complex. |
| Protein Name | Lysine-Specific Demethylase 6b Jmjc Domain-Containing Protein 3 Jumonji Domain-Containing Protein 3 Histone H3-Trimethyl-L-Lysine(27 Demethylase 6b |
| Database Links | Reactome: R-MMU-2559580 Reactome: -MMU-3214842 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Lysine-Specific Demethylase 6b antibody Anti-Jmjc Domain-Containing Protein 3 antibody Anti-Jumonji Domain-Containing Protein 3 antibody Anti-Histone H3-Trimethyl-L-Lysine(27 Demethylase 6b antibody Anti-Kdm6b antibody Anti-Jmjd3 antibody Anti-Kiaa0346 antibody |
Information sourced from Uniprot.org