| Function | Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Demethylation of 'Lys-27' of histone H3 is concomitant with methylation of 'Lys-4' of histone H3, and regulates the recruitment of the PRC1 complex and monoubiquitination of histone H2A. Plays a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression. |
| Protein Name | Lysine-Specific Demethylase 6aHistone Demethylase UtxUbiquitously-Transcribed Tpr Protein On The X ChromosomeUbiquitously-Transcribed X Chromosome Tetratricopeptide Repeat ProteinHistone H3-Trimethyl-L-Lysine(27 Demethylase 6a |
| Database Links | Reactome: R-HSA-3214842Reactome: R-HSA-5617472Reactome: R-HSA-9772755Reactome: R-HSA-9818564Reactome: R-HSA-9821002Reactome: R-HSA-9841922 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Lysine-Specific Demethylase 6a antibodyAnti-Histone Demethylase Utx antibodyAnti-Ubiquitously-Transcribed Tpr Protein On The X Chromosome antibodyAnti-Ubiquitously-Transcribed X Chromosome Tetratricopeptide Repeat Protein antibodyAnti-Histone H3-Trimethyl-L-Lysine(27 Demethylase 6a antibodyAnti-KDM6A antibodyAnti-UTX antibody |
Information sourced from Uniprot.org
