| Function | Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Regulates specific gene transcription through DNA-binding on 5'-CCGCCC-3' motif. May stimulate transcription mediated by nuclear receptors. Involved in transcriptional regulation of Hox proteins during cell differentiation. May participate in transcriptional repression of cytokines such as CXCL12. Plays a role in the regulation of the circadian rhythm and in maintaining the normal periodicity of the circadian clock. In a histone demethylase-independent manner, acts as a coactivator of the CLOCK-BMAL1-mediated transcriptional activation of PER1/2 and other clock-controlled genes and increases histone acetylation at PER1/2 promoters by inhibiting the activity of HDAC1. Seems to act as a transcriptional corepressor for some genes such as MT1F and to favor the proliferation of cancer cells. |
| Protein Name | Lysine-Specific Demethylase 5aHistone Demethylase Jarid1aJumonji/Arid Domain-Containing Protein 1aRetinoblastoma-Binding Protein 2Rbbp-2Histone H3-Trimethyl-L-Lysine(4 Demethylase 5a |
| Database Links | Reactome: R-HSA-3214842Reactome: R-HSA-9821002 |
| Cellular Localisation | NucleusNucleolusOccupies Promoters Of Genes Involved In Rna Metabolism And Mitochondrial Function |
| Alternative Antibody Names | Anti-Lysine-Specific Demethylase 5a antibodyAnti-Histone Demethylase Jarid1a antibodyAnti-Jumonji/Arid Domain-Containing Protein 1a antibodyAnti-Retinoblastoma-Binding Protein 2 antibodyAnti-Rbbp-2 antibodyAnti-Histone H3-Trimethyl-L-Lysine(4 Demethylase 5a antibodyAnti-KDM5A antibodyAnti-JARID1A antibodyAnti-RBBP2 antibodyAnti-RBP2 antibody |
Information sourced from Uniprot.org
