| Function | Probable substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex mediating the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes the ubiquitination of HDAC1.the function seems to depend on KCTD11:KCTD6 oligomerization. Can function as antagonist of the Hedgehog pathway by affecting the nuclear transfer of transcription factor GLI1.the function probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. Inhibits cell growth and tumorigenicity of medulloblastoma (MDB). Involved in regulating protein levels of ANK1 isoform Mu17 probably implicating CUL3-dependent proteasomal degradation. |
| Protein Name | Btb/Poz Domain-Containing Protein Kctd6Kcash3 ProteinPotassium Channel Tetramerization Domain-Containing Protein 6 |
| Database Links | Reactome: R-HSA-8931987Reactome: R-HSA-8951664Reactome: R-HSA-9018519Reactome: R-HSA-983168 |
| Cellular Localisation | CytoplasmMyofibrilSarcomereM LineColocalizes With Ank1 Isoform Mu17 At The M Line In Differentiated Skeletal Muscle Cells And Heart |
| Alternative Antibody Names | Anti-Btb/Poz Domain-Containing Protein Kctd6 antibodyAnti-Kcash3 Protein antibodyAnti-Potassium Channel Tetramerization Domain-Containing Protein 6 antibodyAnti-KCTD6 antibody |
Information sourced from Uniprot.org
