| Short Description : | Rabbit polyclonal anti-KCNV1 (1st Cytoplasmic Domain) for use in IHC and WB in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | IHC/WB |
| Host: | Rabbit |
| Reactivity: | Human/Rat/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Purification: | IgG purified |
| Dilution Range: | IHC, WB. A dilution of 1:200 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Formulation: | Lyophilised |
| Storage Instruction: | Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| Gene Symbol: | KCNV1 |
| Gene ID: | 27012 |
| Uniprot ID: | KCNV1_HUMAN |
| Immunogen: | A synthetic peptide from 1t cytoplasmic domain of human KCNV1 (Kv8.1) conjugated to an immunogenic carrier protein was used as the antigen. |
| Immunogen Region: | 1st Cytoplasmic Domain |
| Specificity: | Specific for KCNV1. |
| Function | Potassium channel subunit that does not form functional channels by itself. Modulates KCNB1 and KCNB2 channel activity by shifting the threshold for inactivation to more negative values and by slowing the rate of inactivation. Can down-regulate the channel activity of KCNB1, KCNB2, KCNC4 and KCND1, possibly by trapping them in intracellular membranes. |
| Protein Name | Potassium Voltage-Gated Channel Subfamily V Member 1Neuronal Potassium Channel Alpha Subunit HnkaVoltage-Gated Potassium Channel Subunit Kv8.1 |
| Database Links | Reactome: R-HSA-1296072 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinHas To Be Associated With Another Potassium Channel Subunit To Get Inserted In The Plasma MembraneRemains Intracellular In The Absence Of Kcnb2 |
| Alternative Antibody Names | Anti-Potassium Voltage-Gated Channel Subfamily V Member 1 antibodyAnti-Neuronal Potassium Channel Alpha Subunit Hnka antibodyAnti-Voltage-Gated Potassium Channel Subunit Kv8.1 antibodyAnti-KCNV1 antibody |
Information sourced from Uniprot.org