Western blot analysis of lysates from rat testis, using KCNU1 Rabbit polyclonal antibody (STJ117166) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit. Exposure time: 90s.

Anti-KCNU1 antibody (920-1149) (STJ117166)

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STJ117166
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Host: Rabbit
Applications: WB/ELISA
Reactivity: Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: WB:1:500-1:2000
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: KCNU1
Gene ID: 157855
Uniprot ID: KCNU1_HUMAN
Immunogen Region: 920-1149
Specificity: Recombinant fusion protein containing a sequence corresponding to amino acids 920-1149 of human KCNU1 (NP_001027006.2).
Immunogen Sequence: LELLQMLVTGGVSSQLEQHL DKDKVYGVADSCTSLLSGRN RCKLGLLSLHETILSDVNPR NTFGQLFCGSLDLFGILCVG LYRIIDEEELNPENKRFVIT RPANEFKLLPSDLVFCAIPF STACYKRNEEFSLQKSYEIV NKASQTTETHSDTNCPPTID SVTETLYSPVYSYQPRTNSL SFPKQIAWNQSRTNSIISSQ IPLGDNAKENERKTSDEVYD EDPFAYSEPL
Tissue Specificity Testis-specific.
Function Testis-specific potassium channel activated by both intracellular pH and membrane voltage that mediates export of K(+). Represents the primary spermatozoan K(+) current. The channel underlies a pH-triggered membrane hyperpolarization during the process of sperm capacitation, as sperm encounter the alkaline environment near the ovum in the female reproductive tract, thereby playing an essential for male fertility.
Protein Name Potassium Channel Subfamily U Member 1
Calcium-Activated Potassium Channel Subunit Alpha-3
Calcium-Activated Potassium Channel - Subfamily M Subunit Alpha-3
Kca5
Slowpoke Homolog 3
Database Links Reactome: R-HSA-1300642
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Cell Projection
Cilium
Flagellum Membrane
Alternative Antibody Names Anti-Potassium Channel Subfamily U Member 1 antibody
Anti-Calcium-Activated Potassium Channel Subunit Alpha-3 antibody
Anti-Calcium-Activated Potassium Channel - Subfamily M Subunit Alpha-3 antibody
Anti-Kca5 antibody
Anti-Slowpoke Homolog 3 antibody
Anti-KCNU1 antibody
Anti-KCNMA3 antibody
Anti-KCNMC1 antibody
Anti-SLO3 antibody

Information sourced from Uniprot.org

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