| Short Description : | Rabbit polyclonal KCNU1 (920-1149) antibody for use in WB and ELISA in rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | KCNU1 |
| Gene ID: | 157855 |
| Uniprot ID: | KCNU1_HUMAN |
| Immunogen Region: | 920-1149 |
| Immunogen Sequence: | LELLQMLVTGGVSSQLEQHL DKDKVYGVADSCTSLLSGRN RCKLGLLSLHETILSDVNPR NTFGQLFCGSLDLFGILCVG LYRIIDEEELNPENKRFVIT RPANEFKLLPSDLVFCAIPF STACYKRNEEFSLQKSYEIV NKASQTTETHSDTNCPPTID SVTETLYSPVYSYQPRTNSL SFPKQIAWNQSRTNSIISSQ IPLGDNAKENERKTSDEVYD EDPFAYSEPL |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 920-1149 of human KCNU1 (NP_001027006.2). |
| Tissue Specificity | Testis-specific. |
| Function | Testis-specific potassium channel activated by both intracellular pH and membrane voltage that mediates export of K(+). Represents the primary spermatozoan K(+) current. The channel underlies a pH-triggered membrane hyperpolarization during the process of sperm capacitation, as sperm encounter the alkaline environment near the ovum in the female reproductive tract, thereby playing an essential for male fertility. |
| Protein Name | Potassium Channel Subfamily U Member 1Calcium-Activated Potassium Channel Subunit Alpha-3Calcium-Activated Potassium Channel - Subfamily M Subunit Alpha-3Kca5Slowpoke Homolog 3 |
| Database Links | Reactome: R-HSA-1300642 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinCell ProjectionCiliumFlagellum Membrane |
| Alternative Antibody Names | Anti-Potassium Channel Subfamily U Member 1 antibodyAnti-Calcium-Activated Potassium Channel Subunit Alpha-3 antibodyAnti-Calcium-Activated Potassium Channel - Subfamily M Subunit Alpha-3 antibodyAnti-Kca5 antibodyAnti-Slowpoke Homolog 3 antibodyAnti-KCNU1 antibodyAnti-KCNMA3 antibodyAnti-KCNMC1 antibodyAnti-SLO3 antibody |
Information sourced from Uniprot.org
