Anti-KCNQ4 antibody (Internal) (STJ71324)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-KCNQ4 (Internal) is suitable for use in ELISA and Western Blot research applications. |
| Applications | Pep-ELISA/WB |
| Host | Goat |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:4000.WB: Approx 70kDa band observed in Human Brain (Cerebellum) lysates (calculated MW of 71.2kDa according to NP_751895.1). Recommended concentration: 1-3µg/ml. |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | KCNQ4 |
| Gene ID | 9132 |
| Uniprot ID | KCNQ4_HUMAN |
| Accession Number | NP_004691.2; NP_751895.1 |
| Immunogen Region | Internal |
| Immunogen Sequence | DKGPSDAEVVDE |
| Specificity | This antibody is expected to recognise both reported isoforms (NP_004691.2; NP_751895.1) ; may cross-react in Mouse;Concentration=0.5 mg/mL" |
Additional Info
| Function | Pore-forming subunit of the voltage-gated potassium (Kv) channel involved in the regulation of sensory cells excitability in the cochlea. KCNQ4/Kv7.4 channel is composed of 4 pore-forming subunits assembled as tetramers. Promotes the outflow of potassium ions in the repolarization phase of action potential which plays a role in regulating membrane potential of excitable cells. The channel conducts a slowly activating and deactivating current. Current often shows some inward rectification at positive potentials. Channel may be selectively permeable in vitro to other cations besides potassium, in decreasing order of affinity K(+) = Rb(+) > Cs(+) > Na(+). Important for normal physiological function of inner ear such as sensory perception of sound. |
| Protein Name | Potassium Voltage-Gated Channel Subfamily Kqt Member 4Kqt-Like 4Potassium Channel Subunit Alpha Kvlqt4Voltage-Gated Potassium Channel Subunit Kv7.4 |
| Database Links | Reactome: R-HSA-1296072Reactome: R-HSA-9662360Reactome: R-HSA-9662361 |
| Cellular Localisation | Basal Cell MembraneMulti-Pass Membrane ProteinSituated At The Basal Membrane Of Cochlear Outer Hair Cells |
| Alternative Antibody Names | Anti-Potassium Voltage-Gated Channel Subfamily Kqt Member 4 antibodyAnti-Kqt-Like 4 antibodyAnti-Potassium Channel Subunit Alpha Kvlqt4 antibodyAnti-Voltage-Gated Potassium Channel Subunit Kv7.4 antibodyAnti-KCNQ4 antibody |
Information sourced from Uniprot.org