| Host: |
Rabbit |
| Applications: |
IHC/WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-KCNQ4 (C-Term) is suitable for use in Immunohistochemistry and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Lyophilised |
| Purification: |
IgG purified |
| Dilution Range: |
IHC, WB. A dilution of 1:200 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Storage Instruction: |
Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| Gene Symbol: |
KCNQ4 |
| Gene ID: |
9132 |
| Uniprot ID: |
KCNQ4_HUMAN |
| Immunogen Region: |
C-Term |
| Specificity: |
Specific for KCNQ4. |
| Immunogen: |
A synthetic peptide from c-terminal region of human KCNQ4 (Kv7.4) conjugated to an immunogenic carrier protein was used as the antigen. |
| Function | Pore-forming subunit of the voltage-gated potassium (Kv) channel involved in the regulation of sensory cells excitability in the cochlea. KCNQ4/Kv7.4 channel is composed of 4 pore-forming subunits assembled as tetramers. Promotes the outflow of potassium ions in the repolarization phase of action potential which plays a role in regulating membrane potential of excitable cells. The channel conducts a slowly activating and deactivating current. Current often shows some inward rectification at positive potentials. Channel may be selectively permeable in vitro to other cations besides potassium, in decreasing order of affinity K(+) = Rb(+) > Cs(+) > Na(+). Important for normal physiological function of inner ear such as sensory perception of sound. |
| Protein Name | Potassium Voltage-Gated Channel Subfamily Kqt Member 4Kqt-Like 4Potassium Channel Subunit Alpha Kvlqt4Voltage-Gated Potassium Channel Subunit Kv7.4 |
| Database Links | Reactome: R-HSA-1296072Reactome: R-HSA-9662360Reactome: R-HSA-9662361 |
| Cellular Localisation | Basal Cell MembraneMulti-Pass Membrane ProteinSituated At The Basal Membrane Of Cochlear Outer Hair Cells |
| Alternative Antibody Names | Anti-Potassium Voltage-Gated Channel Subfamily Kqt Member 4 antibodyAnti-Kqt-Like 4 antibodyAnti-Potassium Channel Subunit Alpha Kvlqt4 antibodyAnti-Voltage-Gated Potassium Channel Subunit Kv7.4 antibodyAnti-KCNQ4 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
