| Host: |
Rabbit |
| Applications: |
IHC/WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-KCNMB3 (N-Term) is suitable for use in Immunohistochemistry and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Lyophilised |
| Purification: |
IgG purified |
| Dilution Range: |
IHC, WB. A dilution of 1:300 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Storage Instruction: |
Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| Gene Symbol: |
KCNMB3 |
| Gene ID: |
27094 |
| Uniprot ID: |
KCMB3_HUMAN |
| Immunogen Region: |
N-Term |
| Specificity: |
Specific for KCNMB3. |
| Immunogen: |
A synthetic peptide from the n-terminal region of human KCNMB3 (Maxi K channel subunit beta-3) conjugated to an immunogenic carrier protein was used as the immunogen. The antigen is homologous in rat and mouse. |
| Post Translational Modifications | N-glycosylated. The extracellular domain contains disulfide bond essential for the gating mechanism. |
| Function | Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Alters the functional properties of the current expressed by the KCNMA1 channel. Isoform 2, isoform 3 and isoform 4 partially inactivate the current of KCNBMA. Isoform 4 induces a fast and incomplete inactivation of KCNMA1 channel that is detectable only at large depolarizations. In contrast, isoform 1 does not induce detectable inactivation of KCNMA1. Two or more subunits of KCNMB3 are required to block the KCNMA1 tetramer. |
| Protein Name | Calcium-Activated Potassium Channel Subunit Beta-3Bk Channel Subunit Beta-3Bkbeta3Hbeta3Calcium-Activated Potassium Channel - Subfamily M Subunit Beta-3Charybdotoxin Receptor Subunit Beta-3K(Vcabeta-3Maxi K Channel Subunit Beta-3Slo-Beta-3 |
| Database Links | Reactome: R-HSA-1296052Reactome: R-HSA-418457 |
| Cellular Localisation | MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Calcium-Activated Potassium Channel Subunit Beta-3 antibodyAnti-Bk Channel Subunit Beta-3 antibodyAnti-Bkbeta3 antibodyAnti-Hbeta3 antibodyAnti-Calcium-Activated Potassium Channel - Subfamily M Subunit Beta-3 antibodyAnti-Charybdotoxin Receptor Subunit Beta-3 antibodyAnti-K(Vcabeta-3 antibodyAnti-Maxi K Channel Subunit Beta-3 antibodyAnti-Slo-Beta-3 antibodyAnti-KCNMB3 antibodyAnti-KCNMB2 antibodyAnti-KCNMBL antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
