Anti-KCNMB3 antibody (N-Term) (STJ13101276)

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STJ13101276-100
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Host: Rabbit
Applications: IHC/WB
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit polyclonal antibody anti-KCNMB3 (N-Term) is suitable for use in Immunohistochemistry and Western Blot research applications.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Lyophilised
Purification: IgG purified
Dilution Range: IHC, WB. A dilution of 1:300 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.
Storage Instruction: Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Gene Symbol: KCNMB3
Gene ID: 27094
Uniprot ID: KCMB3_HUMAN
Immunogen Region: N-Term
Specificity: Specific for KCNMB3.
Immunogen: A synthetic peptide from the n-terminal region of human KCNMB3 (Maxi K channel subunit beta-3) conjugated to an immunogenic carrier protein was used as the immunogen. The antigen is homologous in rat and mouse.
Post Translational Modifications N-glycosylated. The extracellular domain contains disulfide bond essential for the gating mechanism.
Function Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Alters the functional properties of the current expressed by the KCNMA1 channel. Isoform 2, isoform 3 and isoform 4 partially inactivate the current of KCNBMA. Isoform 4 induces a fast and incomplete inactivation of KCNMA1 channel that is detectable only at large depolarizations. In contrast, isoform 1 does not induce detectable inactivation of KCNMA1. Two or more subunits of KCNMB3 are required to block the KCNMA1 tetramer.
Protein Name Calcium-Activated Potassium Channel Subunit Beta-3
Bk Channel Subunit Beta-3
Bkbeta3
Hbeta3
Calcium-Activated Potassium Channel - Subfamily M Subunit Beta-3
Charybdotoxin Receptor Subunit Beta-3
K(Vcabeta-3
Maxi K Channel Subunit Beta-3
Slo-Beta-3
Database Links Reactome: R-HSA-1296052
Reactome: R-HSA-418457
Cellular Localisation Membrane
Multi-Pass Membrane Protein
Alternative Antibody Names Anti-Calcium-Activated Potassium Channel Subunit Beta-3 antibody
Anti-Bk Channel Subunit Beta-3 antibody
Anti-Bkbeta3 antibody
Anti-Hbeta3 antibody
Anti-Calcium-Activated Potassium Channel - Subfamily M Subunit Beta-3 antibody
Anti-Charybdotoxin Receptor Subunit Beta-3 antibody
Anti-K(Vcabeta-3 antibody
Anti-Maxi K Channel Subunit Beta-3 antibody
Anti-Slo-Beta-3 antibody
Anti-KCNMB3 antibody
Anti-KCNMB2 antibody
Anti-KCNMBL antibody

Information sourced from Uniprot.org

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