Anti-KCNJ11/KATP/ antibody (Internal) (STJ71166)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-KCNJ11/KATP/ (Internal) is suitable for use in ELISA, Western Blot and Immunohistochemistry research applications. |
| Applications | Pep-ELISA/WB/IHC |
| Host | Goat |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:32000.WB: Approx 45-48kDa band observed in Human Skeletal Muscle lysates (calculated MW of 43.5kDa according to NP_000516.3). Recommended concentration: 0.1-0.3µg/ml.IHC: In paraffin embedd |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | KCNJ11 |
| Gene ID | 3767 |
| Uniprot ID | KCJ11_HUMAN |
| Accession Number | NP_000516.3 |
| Immunogen Region | Internal |
| Immunogen Sequence | AEDPAKPRYRARQ |
| Specificity | This antibody is expected to recognise isoform 1 (NP_000516.3) only. |
Additional Info
| Function | This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium.as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium. Subunit of ATP-sensitive potassium channels (KATP). Can form cardiac and smooth muscle-type KATP channels with ABCC9. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation. |
| Protein Name | Atp-Sensitive Inward Rectifier Potassium Channel 11IkatpInward Rectifier K(+ Channel Kir6.2Potassium Channel - Inwardly Rectifying Subfamily J Member 11 |
| Database Links | Reactome: R-HSA-1296025Reactome: R-HSA-382556Reactome: R-HSA-422356Reactome: R-HSA-5578775Reactome: R-HSA-5678420Reactome: R-HSA-5683177 |
| Cellular Localisation | MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Atp-Sensitive Inward Rectifier Potassium Channel 11 antibodyAnti-Ikatp antibodyAnti-Inward Rectifier K(+ Channel Kir6.2 antibodyAnti-Potassium Channel - Inwardly Rectifying Subfamily J Member 11 antibodyAnti-KCNJ11 antibody |
Information sourced from Uniprot.org