| Host: |
Rabbit |
| Applications: |
IHC/WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-KCNH3 (100-150 aa) is suitable for use in Immunohistochemistry and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Lyophilised |
| Purification: |
IgG purified |
| Dilution Range: |
IHC, WB. A dilution of 1:300 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Storage Instruction: |
Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| Gene Symbol: |
KCNH3 |
| Gene ID: |
23416 |
| Uniprot ID: |
KCNH3_HUMAN |
| Immunogen Region: |
100-150 aa |
| Specificity: |
Specific for KCNH3. |
| Immunogen: |
A synthetic peptide from aa region 100-150 of human KCNH3 conjugated to blue carrier protein was used as the antigen. |
| Post Translational Modifications | N-glycosylated. N-glycosylation mediates traffick to the cell membrane but is not necessary for voltage-gated potassium channel activity. |
| Function | Pore-forming (alpha) subunit of a voltage-gated inwardly rectifying potassium channel. Charactherized by a fast rate of activation during depolarization followed by a rapid inactivation at much more depolarized value causing inward rectification due to a C-type inactivation mechanism. Exhibits a rapid recovery from inactivation. |
| Protein Name | Voltage-Gated Inwardly Rectifying Potassium Channel Kcnh3Brain-Specific Eag-Like Channel 1Bec1Ether-A-Go-Go-Like Potassium Channel 2Elk Channel 2Elk2Potassium Voltage-Gated Channel Subfamily H Member 3Voltage-Gated Potassium Channel Subunit Kv12.2 |
| Database Links | Reactome: R-HSA-1296072 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinExpression On The Cell Membrane Requires At Least One Of The Three Glycosylation Sites To Carry A Sugar Chain Irrespective Of Their Positions |
| Alternative Antibody Names | Anti-Voltage-Gated Inwardly Rectifying Potassium Channel Kcnh3 antibodyAnti-Brain-Specific Eag-Like Channel 1 antibodyAnti-Bec1 antibodyAnti-Ether-A-Go-Go-Like Potassium Channel 2 antibodyAnti-Elk Channel 2 antibodyAnti-Elk2 antibodyAnti-Potassium Voltage-Gated Channel Subfamily H Member 3 antibodyAnti-Voltage-Gated Potassium Channel Subunit Kv12.2 antibodyAnti-KCNH3 antibodyAnti-KIAA1282 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
