| Host: | Rabbit |
| Applications: | IHC/WB |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-KCNH3 (100-150 aa) is suitable for use in Immunohistochemistry and Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Lyophilised |
| Purification: | IgG purified |
| Dilution Range: | IHC, WB. A dilution of 1:300 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Storage Instruction: | Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| Gene Symbol: | KCNH3 |
| Gene ID: | 23416 |
| Uniprot ID: | KCNH3_HUMAN |
| Immunogen Region: | 100-150 aa |
| Specificity: | Specific for KCNH3. |
| Immunogen: | A synthetic peptide from aa region 100-150 of human KCNH3 conjugated to blue carrier protein was used as the antigen. |
| Post Translational Modifications | N-glycosylated. N-glycosylation mediates traffick to the cell membrane but is not necessary for voltage-gated potassium channel activity. |
| Function | Pore-forming (alpha) subunit of a voltage-gated inwardly rectifying potassium channel. Charactherized by a fast rate of activation during depolarization followed by a rapid inactivation at much more depolarized value causing inward rectification due to a C-type inactivation mechanism. Exhibits a rapid recovery from inactivation. |
| Protein Name | Voltage-Gated Inwardly Rectifying Potassium Channel Kcnh3 Brain-Specific Eag-Like Channel 1 Bec1 Ether-A-Go-Go-Like Potassium Channel 2 Elk Channel 2 Elk2 Potassium Voltage-Gated Channel Subfamily H Member 3 Voltage-Gated Potassium Channel Subunit Kv12.2 |
| Database Links | Reactome: R-HSA-1296072 |
| Cellular Localisation | Cell Membrane Multi-Pass Membrane Protein Expression On The Cell Membrane Requires At Least One Of The Three Glycosylation Sites To Carry A Sugar Chain Irrespective Of Their Positions |
| Alternative Antibody Names | Anti-Voltage-Gated Inwardly Rectifying Potassium Channel Kcnh3 antibody Anti-Brain-Specific Eag-Like Channel 1 antibody Anti-Bec1 antibody Anti-Ether-A-Go-Go-Like Potassium Channel 2 antibody Anti-Elk Channel 2 antibody Anti-Elk2 antibody Anti-Potassium Voltage-Gated Channel Subfamily H Member 3 antibody Anti-Voltage-Gated Potassium Channel Subunit Kv12.2 antibody Anti-KCNH3 antibody Anti-KIAA1282 antibody |
Information sourced from Uniprot.org