Anti-KCNH3 antibody (100-150 aa) (STJ13101619)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide from aa region 100-150 of human KCNH3 conjugated to blue carrier protein was used as the antigen.
General Information
| Short Description | Rabbit polyclonal anti-KCNH3 (100-150 aa) for use in IHC and WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/WB |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | IgG purified |
| Dilution Range | IHC, WB. A dilution of 1:300 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Formulation | Lyophilised |
| Storage Instruction | Maintain the lyophilised/reconstituted antibodies frozen at-20ยฐC for long term storage and refrigerated at 2-8ยฐC for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
Target Information
| Gene Symbol | KCNH3 |
| Gene ID | 23416 |
| Uniprot ID | KCNH3_HUMAN |
| Immunogen | A synthetic peptide from aa region 100-150 of human KCNH3 conjugated to blue carrier protein was used as the antigen. |
| Immunogen Region | 100-150 aa |
| Specificity | Specific for KCNH3. |
Additional Info
| Post Translational Modifications | N-glycosylated. N-glycosylation mediates traffick to the cell membrane but is not necessary for voltage-gated potassium channel activity. |
| Function | Pore-forming (alpha) subunit of a voltage-gated inwardly rectifying potassium channel. Charactherized by a fast rate of activation during depolarization followed by a rapid inactivation at much more depolarized value causing inward rectification due to a C-type inactivation mechanism. Exhibits a rapid recovery from inactivation. |
| Protein Name | Voltage-Gated Inwardly Rectifying Potassium Channel Kcnh3Brain-Specific Eag-Like Channel 1Bec1Ether-A-Go-Go-Like Potassium Channel 2Elk Channel 2Elk2Potassium Voltage-Gated Channel Subfamily H Member 3Voltage-Gated Potassium Channel Subunit Kv12.2 |
| Database Links | Reactome: R-HSA-1296072 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinExpression On The Cell Membrane Requires At Least One Of The Three Glycosylation Sites To Carry A Sugar Chain Irrespective Of Their Positions |
| Alternative Antibody Names | Anti-Voltage-Gated Inwardly Rectifying Potassium Channel Kcnh3 antibodyAnti-Brain-Specific Eag-Like Channel 1 antibodyAnti-Bec1 antibodyAnti-Ether-A-Go-Go-Like Potassium Channel 2 antibodyAnti-Elk Channel 2 antibodyAnti-Elk2 antibodyAnti-Potassium Voltage-Gated Channel Subfamily H Member 3 antibodyAnti-Voltage-Gated Potassium Channel Subunit Kv12.2 antibodyAnti-KCNH3 antibodyAnti-KIAA1282 antibody |
Information sourced from Uniprot.org