| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-KCNE1 (1-100) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
KCNE1 |
| Gene ID: |
3753 |
| Uniprot ID: |
KCNE1_HUMAN |
| Immunogen Region: |
1-100 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human KCNE1 (NP_000210.2). |
| Immunogen Sequence: |
MILSNTTAVTPFLTKLWQET VQQGGNMSGLARRSPRSSDG KLEALYVLMVLGFFGFFTLG IMLSYIRSKKLEHSNDPFNV YIESDAWQEKDKAYVQARVL |
| Tissue Specificity | Expressed in lung, kidney, testis, ovaries, small intestine, peripheral blood leukocytes. Expressed in the heart. Not detected in pancreas, spleen, prostate and colon. Restrictively localized in the apical membrane portion of epithelial cells. |
| Post Translational Modifications | Phosphorylation inhibits the potassium current. N-glycosylation at Asn-26 occurs post-translationally, and requires prior cotranslational glycosylation at Asn-5. |
| Function | Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1. Assembled with KCNQ1/KVLQT1 is proposed to form the slowly activating delayed rectifier cardiac potassium (IKs) channel. The outward current reaches its steady state only after 50 seconds. Assembled with KCNH2/HERG may modulate the rapidly activating component of the delayed rectifying potassium current in heart (IKr). |
| Protein Name | Potassium Voltage-Gated Channel Subfamily E Member 1Delayed Rectifier Potassium Channel Subunit IskIks Producing Slow Voltage-Gated Potassium Channel Subunit Beta MinkMinimal Potassium Channel |
| Database Links | Reactome: R-HSA-5576890Reactome: R-HSA-5576893 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinApical Cell MembraneMembrane RaftColocalizes With Kcnb1 At The Plasma MembraneTargets To The Membrane Raft When Associated With Kcnq1 |
| Alternative Antibody Names | Anti-Potassium Voltage-Gated Channel Subfamily E Member 1 antibodyAnti-Delayed Rectifier Potassium Channel Subunit Isk antibodyAnti-Iks Producing Slow Voltage-Gated Potassium Channel Subunit Beta Mink antibodyAnti-Minimal Potassium Channel antibodyAnti-KCNE1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
