| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
KCNE1 |
| Gene ID: |
3753 |
| Uniprot ID: |
KCNE1_HUMAN |
| Immunogen Region: |
1-100 |
| Specificity: |
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human KCNE1 (NP_000210.2). |
| Immunogen Sequence: |
MILSNTTAVTPFLTKLWQET VQQGGNMSGLARRSPRSSDG KLEALYVLMVLGFFGFFTLG IMLSYIRSKKLEHSNDPFNV YIESDAWQEKDKAYVQARVL |
| Tissue Specificity | Expressed in lung, kidney, testis, ovaries, small intestine, peripheral blood leukocytes. Expressed in the heart. Not detected in pancreas, spleen, prostate and colon. Restrictively localized in the apical membrane portion of epithelial cells. |
| Post Translational Modifications | Phosphorylation inhibits the potassium current. N-glycosylation at Asn-26 occurs post-translationally, and requires prior cotranslational glycosylation at Asn-5. |
| Function | Ancillary protein that functions as a regulatory subunit of the voltage-gated potassium (Kv) channel complex composed of pore-forming and potassium-conducting alpha subunits and of regulatory beta subunits. KCNE1 beta subunit modulates the gating kinetics and enhances stability of the channel complex. Alters the gating of the delayed rectifier Kv channel containing KCNB1 alpha subunit. Associates with KCNQ1/KVLQT1 alpha subunit to form the slowly activating delayed rectifier cardiac potassium (IKs) channel responsible for ventricular muscle action potential repolarization. The outward current reaches its steady state only after 50 seconds (Probable). Assembly with KCNH2/HERG alpha subunit Kv channel may regulate the rapidly activating component of the delayed rectifying potassium current (IKr) in heart. |
| Protein Name | Potassium Voltage-Gated Channel Subfamily E Member 1Delayed Rectifier Potassium Channel Subunit IskIks Producing Slow Voltage-Gated Potassium Channel Subunit Beta MinkMinimal Potassium ChannelMink |
| Database Links | Reactome: R-HSA-5576890Reactome: R-HSA-5576893 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinApical Cell MembraneMembrane RaftColocalizes With Kcnb1 At The Plasma MembraneTargets To The Membrane Raft When Associated With Kcnq1 |
| Alternative Antibody Names | Anti-Potassium Voltage-Gated Channel Subfamily E Member 1 antibodyAnti-Delayed Rectifier Potassium Channel Subunit Isk antibodyAnti-Iks Producing Slow Voltage-Gated Potassium Channel Subunit Beta Mink antibodyAnti-Minimal Potassium Channel antibodyAnti-Mink antibodyAnti-KCNE1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
