| Host: | Rabbit |
| Applications: | WB/IHC/IF/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Voltage-gated potassium channel subunit beta-3 channel subunit beta-3 (293-342 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000IHC 1:100-1:300ELISA 1:10000IF 1:50-200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | KCNAB3 |
| Gene ID: | 9196 |
| Uniprot ID: | KCAB3_HUMAN |
| Immunogen Region: | 293-342 aa |
| Specificity: | KV Beta.3 Polyclonal Antibody detects endogenous levels of KV Beta.3 protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human KCNAB3 at the amino acid range 293-342 |
| Function | Regulatory subunit of the voltage-gated potassium (Kv) channels composed of pore-forming and potassium-conducting alpha subunits and of regulatory beta subunit. The beta-3/KCNAB3 subunit may mediate closure of potassium channels. Increases inactivation of Kv1.5/KCNA5 alpha subunit-containing channels. May display nicotinamide adenine dinucleotide phosphate (NADPH)-dependent aldoketoreductase activity. The binding of oxidized and reduced NADP(H) cofactors may be required for the regulation of potassium channel activity. |
| Protein Name | Voltage-Gated Potassium Channel Subunit Beta-3K(+ Channel Subunit Beta-3Kv-Beta-3 |
| Database Links | Reactome: R-HSA-1296072 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Voltage-Gated Potassium Channel Subunit Beta-3 antibodyAnti-K(+ Channel Subunit Beta-3 antibodyAnti-Kv-Beta-3 antibodyAnti-KCNAB3 antibodyAnti-KCNA3B antibody |
Information sourced from Uniprot.org