| Host: |
Rabbit |
| Applications: |
WB/IF/ICC/ELISA |
| Reactivity: |
Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:1000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
KCNAB2 |
| Gene ID: |
8514 |
| Uniprot ID: |
KCAB2_HUMAN |
| Immunogen Region: |
1-40 |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-40 of human KCNAB2 (NP_003627.1). |
| Immunogen Sequence: |
MYPESTTGSPARLSLRQTGS PGMIYSTRYGSPKRQLQFYR |
| Tissue Specificity | Detected in myelinated nerve fibers in the spinal cord, in the juxtaparanodal region of the nodes of Ranvier, but also in the paranodal region. Detected in hippocampus (at protein level). Detected in hippocampus. |
| Post Translational Modifications | Phosphorylated by PRKCZ.may be regulated by incorporation in a complex composed of PRKCZ and SQSTM1. |
| Function | Regulatory subunit of the voltage-gated potassium (Kv) Shaker channels composed of pore-forming and potassium-conducting alpha subunits and of regulatory beta subunits. The beta-2/KCNAB2 cytoplasmic subunit promotes potassium channel closure via a mechanism that does not involve physical obstruction of the channel pore. Promotes the inactivation of Kv1.4/KCNA4 and Kv1.5/KCNA5 alpha subunit-containing channels. Displays nicotinamide adenine dinucleotide phosphate (NADPH)-dependent aldoketoreductase activity by catalyzing the NADPH-dependent reduction of a wide range of aldehyde and ketone substrates. Substrate specificity includes methylglyoxal, 9,10-phenanthrenequinone, prostaglandin J2, 4-nitrobenzaldehyde, 4-nitroacetophenone and 4-oxo-trans-2-nonenal (in vitro, no physiological substrate identified yet). The binding of oxidized and reduced nucleotide alters Kv channel gating and may contribute to dynamic fine tuning of cell excitability. Contributes to the regulation of nerve signaling, and prevents neuronal hyperexcitability. |
| Protein Name | Voltage-Gated Potassium Channel Subunit Beta-2K(+ Channel Subunit Beta-2Kv-Beta-2Hkvbeta2 |
| Database Links | Reactome: R-HSA-1296072Reactome: R-HSA-6798695 |
| Cellular Localisation | CytoplasmMembranePeripheral Membrane ProteinCytoplasmic SideCell MembraneCell ProjectionAxonSynapseSynaptosomeCytoskeletonRecruited To The Cytoplasmic Side Of The Cell Membrane Via Its Interaction With Pore-Forming Potassium Channel Alpha SubunitsAssociates With Microtubules When Unphosphorylated |
| Alternative Antibody Names | Anti-Voltage-Gated Potassium Channel Subunit Beta-2 antibodyAnti-K(+ Channel Subunit Beta-2 antibodyAnti-Kv-Beta-2 antibodyAnti-Hkvbeta2 antibodyAnti-KCNAB2 antibodyAnti-KCNA2B antibodyAnti-KCNK2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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