| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | KAZN |
| Gene ID: | 23254 |
| Uniprot ID: | KAZRN_HUMAN |
| Immunogen Region: | 586-775 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 586-775 of human KAZN (NP_963922.2). |
| Immunogen Sequence: | YQVNFSREALQERRARCETQ NIDPVVWTNQRVLKWVRDID LKEYADNLTNSGVHGAVLVL EPTFNAEAMATALGIPSGKH ILRRHLAEEMSAVFHPANST GIREAERFGTPPGRASSVTR AGKEENSSGLKYKAGRLPLG KIGRGFSSKDPDFHDDYGSL QNEDCGDDDPQSRLEQCRLE GYNSLEVTNV |
| Tissue Specificity | Isoform 2, isoform 3 and isoform 4 are expressed in several cell lines including keratinocytes and bladder and epidermoid carcinoma (at protein level). Isoform 2, isoform 3 and isoform 4 are expressed in hair follicle and interfollicular epidermis (at protein level). |
| Function | Component of the cornified envelope of keratinocytes. May be involved in the interplay between adherens junctions and desmosomes. The function in the nucleus is not known. |
| Protein Name | Kazrin |
| Database Links | Reactome: R-HSA-6809371 |
| Cellular Localisation | CytoplasmCytoskeletonIsoform 2: CytoplasmCell JunctionDesmosomeNucleusObserved At The Apical Plasma Membrane Of KeratinocytesPartially Colocalizes With Ppl And Dp At DesmosomesAnd With Pp At The Interdesmosomal Plasma MembraneColocalizes With Cortical Actin-Based Membrane StructuresIsoform 3: CytoplasmIsoform 4: Cytoplasm |
| Alternative Antibody Names | Anti-Kazrin antibodyAnti-KAZN antibodyAnti-C1orf196 antibodyAnti-KAZ antibodyAnti-KIAA1026 antibodyAnti-HRIHFB2003 antibody |
Information sourced from Uniprot.org