• STJ70450 Flow cytometric analysis of paraformaldehyde fixed A431 cells (blue line) , permeabilized with 0. 5% Triton. Primary incubation 1hr (10ug/ml) followed by Alexa Fluor 488 secondary antibody (1ug/ml). IgG control: Unimmunized goat IgG (black line) followed by Alexa Fluor 488 secondary antibody.
  • STJ70450 (5µg/ml) staining of paraffin embedded Human Cortex. Heat induced antigen retrieval with citrate buffer pH 6, HRP-staining.
  • STJ70450 Negative Control showing staining of paraffin embedded Human Cortex, with no primary antibody.

Anti-Kalirin antibody (C-Term) (STJ70450)

SKU:
STJ70450-100

£312.50
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Host: Goat
Applications: Pep-ELISA/FC/IHC
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Goat polyclonal antibody anti-Kalirin (C-Term) is suitable for use in ELISA, Flow Cytometry and Immunohistochemistry research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 0.5 mg/mL
Dilution Range: Peptide ELISA: antibody detection limit dilution 1:16000.
WB: Preliminary testing showed a band at approx.. 200kDa in Rat Brain lysate, after 0.1ug/ml antibody staining (calculated Mwt. of 192.5 kDa according to XP_038944588.1). Primary incubatio
Storage Instruction: Store at-20°C on receipt and minimise freeze-thaw cycles.
Gene Symbol: KALRN
Gene ID: 8997
Uniprot ID: KALRN_HUMAN
Immunogen Region: C-Term
Accession Number: NP_003938.1; NP_001309918.1; NP_001309919.1; NP_001309920.1; NP_001309921.1
Specificity: This antibody is expected to recognise NP_003938.1; (isoform 2) , NP_001309918..1 (9isoform 5) , NP_001309919.1; (isoform 6) , NP_001309920.1 (isoform 7) , and NP_001309921.1 (isoform 8).
Immunogen Sequence: RWHLGPGDPFSTYV
Post Translational Modifications Autophosphorylated.
Function Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity.
Protein Name Kalirin
Huntingtin-Associated Protein-Interacting Protein
Protein Duo
Serine/Threonine-Protein Kinase With Dbl- And Pleckstrin Homology Domain
Database Links Reactome: R-HSA-193648
Reactome: R-HSA-3928662
Reactome: R-HSA-416476
Reactome: R-HSA-416482
Reactome: R-HSA-5687128
Reactome: R-HSA-8980692
Reactome: R-HSA-9013149
Reactome: R-HSA-9013408
Cellular Localisation Cytoplasm
Cytoskeleton
Associated With The Cytoskeleton
Alternative Antibody Names Anti-Kalirin antibody
Anti-Huntingtin-Associated Protein-Interacting Protein antibody
Anti-Protein Duo antibody
Anti-Serine/Threonine-Protein Kinase With Dbl- And Pleckstrin Homology Domain antibody
Anti-KALRN antibody
Anti-DUET antibody
Anti-DUO antibody
Anti-HAPIP antibody
Anti-TRAD antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance