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Anti-Kalirin antibody (C-Term) (STJ70450)

STJ70450 Flow cytometric analysis of paraformaldehyde fixed A431 cells (blue line) , permeabilized with 0. 5% Triton. Primary incubation 1hr (10ug/ml) followed by Alexa Fluor 488 secondary antibody (1ug/ml). IgG control: Unimmunized goat IgG (black line) followed by Alexa Fluor 488 secondary antibody.
STJ70450 (5µg/ml) staining of paraffin embedded Human Cortex. Heat induced antigen retrieval with citrate buffer pH 6, HRP-staining.
STJ70450 Negative Control showing staining of paraffin embedded Human Cortex, with no primary antibody.

Anti-Kalirin antibody (C-Term) (STJ70450)

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STJ70450-100

£303.50

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General Information
Product Properties
Target Information
Additional Info
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Host:	Goat
Applications:	Pep-ELISA/FC/IHC
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Goat polyclonal antibody anti-Kalirin (C-Term) is suitable for use in ELISA, Flow Cytometry and Immunohistochemistry research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification:	Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration:	0.5 mg/mL
Dilution Range:	IHC-4-5µg/ml FC-Flow cytometric analysis of HepG2 cells. 10ug/ml ELISA-antibody detection limit dilution 1:16000.
Storage Instruction:	Store at-20°C on receipt and minimise freeze-thaw cycles.

Gene Symbol:	KALRN
Gene ID:	8997
Uniprot ID:	KALRN_HUMAN
Immunogen Region:	C-Term
Accession Number:	NP_003938.1; NP_001309918.1; NP_001309919.1; NP_001309920.1; NP_001309921.1
Specificity:	This antibody is expected to recognise NP_003938.1; (isoform 2) , NP_001309918..1 (9isoform 5) , NP_001309919.1; (isoform 6) , NP_001309920.1 (isoform 7) , and NP_001309921.1 (isoform 8).
Immunogen Sequence:	RWHLGPGDPFSTYV

Post Translational Modifications	Autophosphorylated.
Function	Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity.
Protein Name	Kalirin Huntingtin-Associated Protein-Interacting Protein Protein Duo Serine/Threonine-Protein Kinase With Dbl- And Pleckstrin Homology Domain
Database Links	Reactome: R-HSA-193648 Reactome: R-HSA-3928662 Reactome: R-HSA-416476 Reactome: R-HSA-416482 Reactome: R-HSA-5687128 Reactome: R-HSA-8980692 Reactome: R-HSA-9013149 Reactome: R-HSA-9013408
Cellular Localisation	Cytoplasm Cytoskeleton Associated With The Cytoskeleton
Alternative Antibody Names	Anti-Kalirin antibody Anti-Huntingtin-Associated Protein-Interacting Protein antibody Anti-Protein Duo antibody Anti-Serine/Threonine-Protein Kinase With Dbl- And Pleckstrin Homology Domain antibody Anti-KALRN antibody Anti-DUET antibody Anti-DUO antibody Anti-HAPIP antibody Anti-TRAD antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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