Host: | Rabbit |
Applications: | WB/IF/ICC/ELISA |
Reactivity: | Human/Mouse/Rat |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Clonality: | Monoclonal |
Clone ID: | S6MR |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
Purification: | Affinity purification |
Concentration: | Lot specific |
Dilution Range: | WB:1:500-1:1000 IF/ICC:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: | JUP |
Gene ID: | 3728 |
Uniprot ID: | PLAK_HUMAN |
Immunogen Region: | 15-115 |
Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 15-115 of human Gamma-Catenin (P14923). |
Immunogen Sequence: | EWQQTYTYDSGIHSGANTCV PSVSSKGIMEEDEACGRQYT LKKTTTYTQGVPPSQGDLEY QMSTTARAKRVREAMCPGVS GEDSSLLLATQVEGQATNLQ R |
Tissue Specificity | Expressed in the heart (at protein level). |
Post Translational Modifications | May be phosphorylated by FER. |
Function | Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton. |
Protein Name | Junction Plakoglobin Catenin Gamma Desmoplakin Iii Desmoplakin-3 |
Database Links | Reactome: R-HSA-418990 Reactome: R-HSA-5218920 Reactome: R-HSA-6798695 Reactome: R-HSA-6805567 Reactome: R-HSA-6809371 Reactome: R-HSA-8980692 Reactome: R-HSA-9013026 Reactome: R-HSA-9013106 Reactome: R-HSA-9013148 Reactome: R-HSA-9013406 Reactome: R-HSA-9013407 Reactome: R-HSA-9013409 Reactome: R-HSA-9762292 Reactome: R-HSA-9764302 Reactome: R-HSA-9833576 |
Cellular Localisation | Cell Junction Adherens Junction Desmosome Cytoplasm Cytoskeleton Cell Membrane Peripheral Membrane Protein Nucleus Cytoplasmic In A Soluble And Membrane-Associated Form Colocalizes With Dsg4 At Desmosomes |
Alternative Antibody Names | Anti-Junction Plakoglobin antibody Anti-Catenin Gamma antibody Anti-Desmoplakin Iii antibody Anti-Desmoplakin-3 antibody Anti-JUP antibody Anti-CTNNG antibody Anti-DP3 antibody |
Information sourced from Uniprot.org