• Immunofluorescence analysis of NIH-3T3 cells using Gamma-Catenin Rabbit monoclonal antibody (STJ11102006) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.

Anti-JUP antibody (15-115) [S6MR] (STJ11102006)

SKU:
STJ11102006

Shipping:
Free Shipping
Current Stock:
Host: Rabbit
Applications: WB/IF/ICC/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality: Monoclonal
Clone ID: S6MR
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: WB:1:500-1:1000
IF/ICC:1:50-1:200
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: JUP
Gene ID: 3728
Uniprot ID: PLAK_HUMAN
Immunogen Region: 15-115
Specificity: Recombinant fusion protein containing a sequence corresponding to amino acids 15-115 of human Gamma-Catenin (P14923).
Immunogen Sequence: EWQQTYTYDSGIHSGANTCV PSVSSKGIMEEDEACGRQYT LKKTTTYTQGVPPSQGDLEY QMSTTARAKRVREAMCPGVS GEDSSLLLATQVEGQATNLQ R
Tissue Specificity Expressed in the heart (at protein level).
Post Translational Modifications May be phosphorylated by FER.
Function Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton.
Protein Name Junction Plakoglobin
Catenin Gamma
Desmoplakin Iii
Desmoplakin-3
Database Links Reactome: R-HSA-418990
Reactome: R-HSA-5218920
Reactome: R-HSA-6798695
Reactome: R-HSA-6805567
Reactome: R-HSA-6809371
Reactome: R-HSA-8980692
Reactome: R-HSA-9013026
Reactome: R-HSA-9013106
Reactome: R-HSA-9013148
Reactome: R-HSA-9013406
Reactome: R-HSA-9013407
Reactome: R-HSA-9013409
Reactome: R-HSA-9762292
Reactome: R-HSA-9764302
Reactome: R-HSA-9833576
Cellular Localisation Cell Junction
Adherens Junction
Desmosome
Cytoplasm
Cytoskeleton
Cell Membrane
Peripheral Membrane Protein
Nucleus
Cytoplasmic In A Soluble And Membrane-Associated Form
Colocalizes With Dsg4 At Desmosomes
Alternative Antibody Names Anti-Junction Plakoglobin antibody
Anti-Catenin Gamma antibody
Anti-Desmoplakin Iii antibody
Anti-Desmoplakin-3 antibody
Anti-JUP antibody
Anti-CTNNG antibody
Anti-DP3 antibody

Information sourced from Uniprot.org