Anti-JAML antibody (STJ191879)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from part of the human protein
General Information
| Short Description | Rabbit polyclonal anti-Junctional adhesion molecule-like for use in WB and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | JAML |
| Gene ID | 120425 |
| Uniprot ID | JAML_HUMAN |
| Immunogen | Synthesized peptide derived from part of the human protein |
| Specificity | JAML1 Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Function | Transmembrane protein of the plasma membrane of leukocytes that control their migration and activation through interaction with CXADR, a plasma membrane receptor found on adjacent epithelial and endothelial cells. The interaction between both receptors mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair. It also controls the transmigration of leukocytes within epithelial and endothelial tissues through adhesive interactions with epithelial and endothelial CXADR. |
| Protein Name | Junctional Adhesion Molecule-LikeAdhesion Molecule Interacting With Cxadr Antigen 1Dendritic Cell-Specific Protein Crea7-1 |
| Database Links | Reactome: R-HSA-198933Reactome: R-HSA-202733 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinCell JunctionLocalized At The Plasma Membrane And Enriched In Areas Of Cell-Cell Contacts |
| Alternative Antibody Names | Anti-Junctional Adhesion Molecule-Like antibodyAnti-Adhesion Molecule Interacting With Cxadr Antigen 1 antibodyAnti-Dendritic Cell-Specific Protein Crea7-1 antibodyAnti-JAML antibodyAnti-AMICA1 antibodyAnti-UNQ722 antibodyAnti-PRO1387 antibody |
Information sourced from Uniprot.org