| Host: | Rabbit |
| Applications: | WB/IHC |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit monoclonal antibody anti-JAK1 (600-700) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality: | Monoclonal |
| Clone ID: | S8MR |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH7.3. |
| Purification: | Affinity purification |
| Dilution Range: | WB 1:500-1:1000IHC-P 1:50-1:200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | JAK1 |
| Gene ID: | 3716 |
| Uniprot ID: | JAK1_HUMAN |
| Immunogen Region: | 600-700 |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 600-700 of human JAK1 (P23458). |
| Immunogen Sequence: | GTLMDYKDDEGTSEEKKIKV ILKVLDPSHRDISLAFFEAA SMMRQVSHKHIVYLYGVCVR DVENIMVEEFVEGGPLDLFM HRKSDVLTTPWKFKVAKQLA S |
| Tissue Specificity | Expressed at higher levels in primary colon tumors than in normal colon tissue. The expression level in metastatic colon tumors is comparable to the expression level in normal colon tissue. |
| Post Translational Modifications | Autophosphorylated. Phosphorylated by TYK2 on tyrosine residues in response to type-I interferon signaling, leading to its activation. Phosphorylated on tyrosine residues in response to interferon gamma signaling. Dephosphorylation of Tyr-1034 and Tyr-1035 by PTPN2 negatively regulates cytokine-mediated signaling. Ubiquitinated by RNF125.leading to its degradation by the proteasome. |
| Function | Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor as well as interleukin (IL)-10 receptor. Kinase partner for the type I interferon receptor IFNAR2. In response to interferon-binding to IFNAR1-IFNAR2 heterodimer, phosphorylates and activates its binding partner IFNAR2, creating docking sites for STAT proteins. Directly phosphorylates STAT proteins but also activates STAT signaling through the transactivation of other JAK kinases associated with signaling receptors. |
| Protein Name | Tyrosine-Protein Kinase Jak1Janus Kinase 1Jak-1 |
| Database Links | Reactome: R-HSA-1059683Reactome: R-HSA-110056Reactome: R-HSA-112411Reactome: R-HSA-1169408Reactome: R-HSA-1266695Reactome: R-HSA-449836Reactome: R-HSA-5673001Reactome: R-HSA-6783783Reactome: R-HSA-6785807Reactome: R-HSA-6788467Reactome: R-HSA-877300Reactome: R-HSA-877312Reactome: R-HSA-8854691Reactome: R-HSA-8983432Reactome: R-HSA-8984722Reactome: R-HSA-8985947Reactome: R-HSA-9020558Reactome: R-HSA-9020591Reactome: R-HSA-9020956Reactome: R-HSA-9020958Reactome: R-HSA-909733Reactome: R-HSA-912526Reactome: R-HSA-912694Reactome: R-HSA-9674555Reactome: R-HSA-9679191Reactome: R-HSA-9705462Reactome: R-HSA-9705671Reactome: R-HSA-9732724 |
| Cellular Localisation | Endomembrane SystemPeripheral Membrane ProteinWholly IntracellularPossibly Membrane Associated |
| Alternative Antibody Names | Anti-Tyrosine-Protein Kinase Jak1 antibodyAnti-Janus Kinase 1 antibodyAnti-Jak-1 antibodyAnti-JAK1 antibodyAnti-JAK1A antibodyAnti-JAK1B antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
