| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ITSN2 |
| Gene ID: | 50618 |
| Uniprot ID: | ITSN2_HUMAN |
| Immunogen Region: | 500-620 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 500-620 of human ITSN2 (NP_006268.2). |
| Immunogen Sequence: | GKHQQISGRLQDVRLKKQTQ KTELEVLDKQCDLEIMEIKQ LQQELQEYQNKLIYLVPEKQ LLNERIKNMQFSNTPDSGVS LLHKKSLEKEELCQRLKEQL DALEKETASKLSEMDSFNNQ L |
| Tissue Specificity | Expressed in melanocytes. Ubiquitous. Isoform 1 is primarily expressed in adult heart and liver. |
| Function | Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles (CCPs). Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR). Plays a role in dendrite formation by melanocytes. |
| Protein Name | Intersectin-2Sh3 Domain-Containing Protein 1bSh3p18Sh3p18-Like Wasp-Associated Protein |
| Database Links | Reactome: R-HSA-8856825Reactome: R-HSA-8856828Reactome: R-HSA-9013420 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Intersectin-2 antibodyAnti-Sh3 Domain-Containing Protein 1b antibodyAnti-Sh3p18 antibodyAnti-Sh3p18-Like Wasp-Associated Protein antibodyAnti-ITSN2 antibodyAnti-KIAA1256 antibodyAnti-SH3D1B antibodyAnti-SWAP antibody |
Information sourced from Uniprot.org
