| Host: | Goat |
| Applications: | Pep-ELISA/IHC |
| Reactivity: | Human/Mouse/Rat/Dog/Cow |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Goat polyclonal antibody anti-ITPR2 (Internal) is suitable for use in ELISA and Immunohistochemistry research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: | 0.5 mg/mL |
| Dilution Range: | Peptide ELISA: antibody detection limit dilution 1:128000. WB: Preliminary experiments gave an approx 28-30kDa band in Human Heart lysates after 0.1µg/ml antibody staining. Please note that currently we cannot find an explanation in the literatur |
| Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: | ITPR2 |
| Gene ID: | 3709 |
| Uniprot ID: | ITPR2_HUMAN |
| Immunogen Region: | Internal |
| Accession Number: | NP_002214.2 |
| Specificity: | No cross-reactivity expected with other types of ITPR. |
| Immunogen Sequence: | PIEESNILSPVQD |
| Post Translational Modifications | Phosphorylation by cAMP-dependent PKA on Ser-937 increases calcium release. Phosphorylation by CaMK2 on Ser-150 significantly decreases the channel open probability. |
| Function | Inositol 1,4,5-trisphosphate-gated calcium channel that upon inositol 1,4,5-trisphosphate binding transports calcium from the endoplasmic reticulum lumen to cytoplasm. Exists in two states.a long-lived closed state where the channel is essentially 'parked' with only very rare visits to an open state and that ligands facilitate the transition from the 'parked' state into a 'drive' mode represented by periods of bursting activity. |
| Protein Name | Inositol 1 -4 -5-Trisphosphate-Gated Calcium Channel Itpr2 Ip3 Receptor Isoform 2 Ip3r 2 Insp3r2 Inositol 1 -4 -5-Trisphosphate Receptor Type 2 Type 2 Inositol 1 -4 -5-Trisphosphate Receptor Type 2 Insp3 Receptor |
| Database Links | Reactome: R-HSA-112043 Reactome: R-HSA-114508 Reactome: R-HSA-139853 Reactome: R-HSA-1489509 Reactome: R-HSA-2029485 Reactome: R-HSA-2871809 Reactome: R-HSA-381676 Reactome: R-HSA-4086398 Reactome: R-HSA-422356 Reactome: R-HSA-5218921 Reactome: R-HSA-5578775 Reactome: R-HSA-5607763 Reactome: R-HSA-9664323 Reactome: R-HSA-983695 |
| Cellular Localisation | Endoplasmic Reticulum Membrane Multi-Pass Membrane Protein Cytoplasmic Vesicle Secretory Vesicle Membrane Forms Clusters On Endoplasmic Reticulum Membrane Upon Inositol 1 4 5-Trisphosphate Binding |
| Alternative Antibody Names | Anti-Inositol 1 -4 -5-Trisphosphate-Gated Calcium Channel Itpr2 antibody Anti-Ip3 Receptor Isoform 2 antibody Anti-Ip3r 2 antibody Anti-Insp3r2 antibody Anti-Inositol 1 -4 -5-Trisphosphate Receptor Type 2 antibody Anti-Type 2 Inositol 1 -4 -5-Trisphosphate Receptor antibody Anti-Type 2 Insp3 Receptor antibody Anti-ITPR2 antibody |
Information sourced from Uniprot.org