| Tissue Specificity | Widely expressed. Strongly expressed in the primary cilia of renal tubular cells. |
| Post Translational Modifications | May be ubiquitinated via its interaction with APC2. Hydroxylated at Asn-75, most probably by HIF1AN. |
| Function | Required for normal renal development and establishment of left-right axis. Probably acts as a molecular switch between different Wnt signaling pathways. Inhibits the canonical Wnt pathway by targeting cytoplasmic disheveled (DVL1) for degradation by the ubiquitin-proteasome. This suggests that it is required in renal development to oppose the repression of terminal differentiation of tubular epithelial cells by Wnt signaling. Involved in the organization of apical junctions in kidney cells together with NPHP1, NPHP4 and RPGRIP1L/NPHP8. Does not seem to be strictly required for ciliogenesis. |
| Protein Name | InversinInversion Of Embryo Turning HomologNephrocystin-2 |
| Database Links | |
| Cellular Localisation | CytoplasmCytoskeletonSpindleMembranePeripheral Membrane ProteinNucleusCell ProjectionCiliumAssociates With Several Components Of The Cytoskeleton Including CiliaryRandom And Polarized MicrotubulesDuring MitosisIt Is Recruited To Mitotic SpindleFrequently Membrane-AssociatedMembrane Localization Is Dependent Upon Cell-Cell Contacts And Is Redistributed When Cell Adhesion Is Disrupted After Incubation Of The Cell Monolayer With Low-Calcium/Egta Medium |
| Alternative Antibody Names | Anti-Inversin antibodyAnti-Inversion Of Embryo Turning Homolog antibodyAnti-Nephrocystin-2 antibodyAnti-INVS antibodyAnti-INV antibodyAnti-NPHP2 antibody |
Information sourced from Uniprot.org
