| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | INPP4B |
| Gene ID: | 8821 |
| Uniprot ID: | INP4B_HUMAN |
| Immunogen Region: | 380-600 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 380-600 of human INPP4B (NP_003857.2). |
| Immunogen Sequence: | GLRKLLHRFETERRNTGYQF IYYSPENTAKAKEVLSNINQ LQPLIATHADLLLNSASQHS PDSLKNSLKMLSEKTELFVH AFKDQLVRSALLALYTARPG GILKKPPSPKSSTEESSPQD QPPVMRGQDSIPHHSDYDEE EWDRVWANVGKSLNCIIAMV DKLIERDGGSEGSGGNNDGE KEPSLTDAIPSHPREDWYEQ LYPLILTLKDCMGEVVNRAK Q |
| Tissue Specificity | Widely expressed with highest levels occurring in the skeletal muscle and heart. |
| Function | Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate and inositol 3,4-trisphosphate. Plays a role in the late stages of macropinocytosis by dephosphorylating phosphatidylinositol 3,4-bisphosphate in membrane ruffles. The lipid phosphatase activity is critical for tumor suppressor function. Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival. |
| Protein Name | Inositol Polyphosphate 4-Phosphatase Type IiType Ii Inositol 3 -4-Bisphosphate 4-Phosphatase |
| Database Links | Reactome: R-HSA-1660499Reactome: R-HSA-1660516Reactome: R-HSA-1855183 |
| Alternative Antibody Names | Anti-Inositol Polyphosphate 4-Phosphatase Type Ii antibodyAnti-Type Ii Inositol 3 -4-Bisphosphate 4-Phosphatase antibodyAnti-INPP4B antibody |
Information sourced from Uniprot.org