| Short Description : | Rabbit polyclonal ING4 (1-249) antibody for use in WB, IHC-P and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/IHC-P/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.09% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ING4 |
| Gene ID: | 51147 |
| Uniprot ID: | ING4_HUMAN |
| Immunogen Region: | 1-249 |
| Immunogen Sequence: | MAAGMYLEHYLDSIENLPFE LQRNFQLMRDLDQRTEDLKA EIDKLATEYMSSARSLSSEE KLALLKQIQEAYGKCKEFGD DKVQLAMQTYEMVDKHIRRL DTDLARFEADLKEKQIESSD YDSSSSKGKKKGRTQKEKKA ARARSKGKNSDEEAPKTAQK KLKLVRTSPEYGMPSVTFGS VHPSDVLDMPVDPNEPTYCL CHQVSYGEMIGCDNPDCSIE WFHFACVGLTTKPRGKWFC |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-249 of human ING4 (NP_001121054.1). |
| Post Translational Modifications | Citrullination by PADI4 within the nuclear localization signal disrupts the interaction with p53 and increases susceptibility to degradation. |
| Function | Component of HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), and have reduced activity toward histone H4. Through chromatin acetylation it may function in DNA replication. May inhibit tumor progression by modulating the transcriptional output of signaling pathways which regulate cell proliferation. Can suppress brain tumor angiogenesis through transcriptional repression of RELA/NFKB3 target genes when complexed with RELA. May also specifically suppress loss of contact inhibition elicited by activated oncogenes such as MYC. Represses hypoxia inducible factor's (HIF) activity by interacting with HIF prolyl hydroxylase 2 (EGLN1). Can enhance apoptosis induced by serum starvation in mammary epithelial cell line HC11. |
| Protein Name | Inhibitor Of Growth Protein 4P29ing4 |
| Database Links | Reactome: R-HSA-3214847 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Inhibitor Of Growth Protein 4 antibodyAnti-P29ing4 antibodyAnti-ING4 antibodyAnti-My036 antibody |
Information sourced from Uniprot.org
