STJ70185 staining (2µg/ml) of HepG2 lysate (RIPA buffer, 35µg total protein per lane). Primary incubated for 12 hour. Detected by chemiluminescence.

Anti-ING2/ING1L antibody (C-Term) (STJ70185)

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STJ70185-100
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Host: Goat
Applications: Pep-ELISA/WB
Reactivity: Human/Cow
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Goat polyclonal antibody anti-ING2/ING1L (C-Term) is suitable for use in ELISA and Western Blot research applications.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 0.5 mg/mL
Dilution Range: Peptide ELISA: antibody detection limit dilution 1:1000.
WB: Approx 30kDa band observed in hepatocarcinoma HEPG2 lysates (calculated MW of 32.8kDa according to NP_001555). Recommended concentration: 1-3µg/ml.
Storage Instruction: Store at-20°C on receipt and minimise freeze-thaw cycles.
Gene Symbol: ING2
Gene ID: 3622
Uniprot ID: ING2_HUMAN
Immunogen Region: C-Term
Accession Number: NP_001555.1
Immunogen Sequence: DKSTEKTKKDRRSR
Post Translational Modifications Sumoylation enhances its association with SIN3A and is required for binding to some target gene promoters, this is the case for TMEM71.
Function Seems to be involved in p53/TP53 activation and p53/TP53-dependent apoptotic pathways, probably by enhancing acetylation of p53/TP53. Component of a mSin3A-like corepressor complex, which is probably involved in deacetylation of nucleosomal histones. ING2 activity seems to be modulated by binding to phosphoinositides (PtdInsPs).
Protein Name Inhibitor Of Growth Protein 2
Inhibitor Of Growth 1-Like Protein
Ing1lp
P32
P33ing2
Database Links Reactome: R-HSA-3899300
Reactome: R-HSA-6811555
Cellular Localisation Nucleus
Predominantly Nuclear
Localized To Chromatin And Nuclear Matrix
Upon Reduced Ptdins(5)P Levels Seems To Be Released From Chromatin And
At Least Partially
Translocated To The Cytoplasm
Alternative Antibody Names Anti-Inhibitor Of Growth Protein 2 antibody
Anti-Inhibitor Of Growth 1-Like Protein antibody
Anti-Ing1lp antibody
Anti-P32 antibody
Anti-P33ing2 antibody
Anti-ING2 antibody
Anti-ING1L antibody

Information sourced from Uniprot.org

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