| Host: |
Goat |
| Applications: |
Pep-ELISA/WB |
| Reactivity: |
Human/Cow |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Goat polyclonal antibody anti-ING2/ING1L (C-Term) is suitable for use in ELISA and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: |
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: |
0.5 mg/mL |
| Dilution Range: |
Peptide ELISA: antibody detection limit dilution 1:1000.WB: Approx 30kDa band observed in hepatocarcinoma HEPG2 lysates (calculated MW of 32.8kDa according to NP_001555). Recommended concentration: 1-3µg/ml. |
| Storage Instruction: |
Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: |
ING2 |
| Gene ID: |
3622 |
| Uniprot ID: |
ING2_HUMAN |
| Immunogen Region: |
C-Term |
| Accession Number: |
NP_001555.1 |
| Immunogen Sequence: |
DKSTEKTKKDRRSR |
| Post Translational Modifications | Sumoylation enhances its association with SIN3A and is required for binding to some target gene promoters, this is the case for TMEM71. |
| Function | Seems to be involved in p53/TP53 activation and p53/TP53-dependent apoptotic pathways, probably by enhancing acetylation of p53/TP53. Component of a mSin3A-like corepressor complex, which is probably involved in deacetylation of nucleosomal histones. ING2 activity seems to be modulated by binding to phosphoinositides (PtdInsPs). |
| Protein Name | Inhibitor Of Growth Protein 2Inhibitor Of Growth 1-Like ProteinIng1lpP32P33ing2 |
| Database Links | Reactome: R-HSA-3899300Reactome: R-HSA-6811555 |
| Cellular Localisation | NucleusPredominantly NuclearLocalized To Chromatin And Nuclear MatrixUpon Reduced Ptdins(5)P Levels Seems To Be Released From Chromatin AndAt Least PartiallyTranslocated To The Cytoplasm |
| Alternative Antibody Names | Anti-Inhibitor Of Growth Protein 2 antibodyAnti-Inhibitor Of Growth 1-Like Protein antibodyAnti-Ing1lp antibodyAnti-P32 antibodyAnti-P33ing2 antibodyAnti-ING2 antibodyAnti-ING1L antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
