| Tissue Specificity | Widely expressed. Higher expressed in colon-cancer tumor than in normal colon tissues. |
| Post Translational Modifications | Sumoylation enhances its association with SIN3A and is required for binding to some target gene promoters, this is the case for TMEM71. |
| Function | Seems to be involved in p53/TP53 activation and p53/TP53-dependent apoptotic pathways, probably by enhancing acetylation of p53/TP53. Component of a mSin3A-like corepressor complex, which is probably involved in deacetylation of nucleosomal histones. ING2 activity seems to be modulated by binding to phosphoinositides (PtdInsPs). |
| Protein Name | Inhibitor Of Growth Protein 2Inhibitor Of Growth 1-Like ProteinIng1lpP32P33ing2 |
| Database Links | Reactome: R-HSA-3899300Reactome: R-HSA-6811555 |
| Cellular Localisation | NucleusPredominantly NuclearLocalized To Chromatin And Nuclear MatrixUpon Reduced Ptdins(5)P Levels Seems To Be Released From Chromatin AndAt Least PartiallyTranslocated To The Cytoplasm |
| Alternative Antibody Names | Anti-Inhibitor Of Growth Protein 2 antibodyAnti-Inhibitor Of Growth 1-Like Protein antibodyAnti-Ing1lp antibodyAnti-P32 antibodyAnti-P33ing2 antibodyAnti-ING2 antibodyAnti-ING1L antibody |
Information sourced from Uniprot.org
