| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-INADL (450-680) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PATJUniprot ID=INADL_HUMAN" |
| Immunogen Region: |
450-680 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 450-680 of human INADL (NP_795352.2). |
| Immunogen Sequence: |
VRRKTSSSTSPLEPPSDRGT VVEPLKPPALFLTGAVETET NVDGEDEEIKERIDTLKNDN IQALEKLEKVPDSPENELKS RWENLLGPDYEVMVATLDTQ IADDAELQKYSKLLPIHTLR LGVEVDSFDGHHYISSIVSG GPVDTLGLLQPEDELLEVNG MQLYGKSRREAVSFLKEVPP PFTLVCCRRLFDDEASVDEP RRTETSLPETEVDHNMDVNT EEDDDGELALW |
| Tissue Specificity | Expressed in renal tubules (at protein level). Expressed in bladder, testis, ovary, small intestine, colon, heart, skeletal muscle, pancreas and cerebellum in the brain. |
| Function | Scaffolding protein that facilitates the localization of proteins to the cell membrane. Required for the correct formation of tight junctions and epithelial apico-basal polarity. Positively regulates epithelial cell microtubule elongation and cell migration, possibly via facilitating localization of PRKCI/aPKC and PAR3D/PAR3 at the leading edge of migrating cells. Plays a role in the correct reorientation of the microtubule-organizing center during epithelial migration. May regulate the surface expression and/or function of ASIC3 in sensory neurons. May recruit ARHGEF18 to apical cell-cell boundaries. |
| Protein Name | Inad-Like ProteinInadl ProteinHinadlChannel-Interacting Pdz Domain-Containing ProteinPals1-Associated Tight Junction ProteinProtein Associated To Tight Junctions |
| Cellular Localisation | Cell JunctionTight JunctionApical Cell MembranePeripheral Membrane ProteinCytoplasmPerinuclear RegionLocalizes To The Apical Region At The Start Of Epithelial Cell Polarization Then Locates To Tight Junctions As Polarization Is CompletedLocalized In The Paranodal Region Of Myelinating Schwann CellsLocalized To The Leading Edge Of The Actin Cortex Of Migrating Epithelia Cells |
| Alternative Antibody Names | Anti-Inad-Like Protein antibodyAnti-Inadl Protein antibodyAnti-Hinadl antibodyAnti-Channel-Interacting Pdz Domain-Containing Protein antibodyAnti-Pals1-Associated Tight Junction Protein antibodyAnti-Protein Associated To Tight Junctions antibodyAnti-PATJ antibodyAnti-CIPP antibodyAnti-INADL antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
